IYPTNGYTR acetate, a deamidation-sensitive signature peptide, is a deamidation product of Trastuzumab. IYPTNGYTR acetate can be used to monitor in vivo Trastuzumab metabolism.
性状
Solid
体外研究(In Vitro)
IYPTNGYTR is deamidated at pH 7.5 and above, with a higher deamidation rate when the pH increases. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Sealed storage, away from moisturePowder -80°C 2 years;-20°C 1 year
SequenceShortening
IYPTNGYTR
参考文献
[1]. Bults P, et, al. LC-MS/MS-Based Monitoring of In Vivo Protein Biotransformation: Quantitative Determination of Trastuzumab and Its Deamidation Products in Human Plasma. Anal Chem. 2016 Feb 2;88(3):1871-7.
溶解度数据
In Vitro: H2O : 125 mg/mL (109.24 mM; Need ultrasonic)配制储备液