GLP-1(32-36)amide|1417302-71-6|-陌孚医药/Medlife

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GLP-1(32-36)amide

目录号: PL05977 纯度: ≥98%

CAS No. :1417302-71-6

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中文名称	GLP-1(32-36)amide
英文名称	GLP-1(32-36)amide
英文别名	GLP-1(32-36)amide
Cas No.	1417302-71-6
分子式	C₂₅H₅₀N₁₀O₅
分子量	570.73
包装储存	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year

产品详情	GLP-1(32-36)amide，一种衍生自糖调节激素 GLP-1 的 C 末端的五肽。GLP-1(32-36)amide 可抑制糖尿病小鼠的体重增加并调节全身葡萄糖代谢。
生物活性	GLP-1(32-36)amide, a pentapeptide, derived from the C terminus of the glucoregulatory hormone GLP-1. GLP-1(32-36)amide could inhibit weight gain and modulate whole body glucose metabolism in diabetic mice.
性状	Solid
体外研究(In Vitro)	GLP-1(32-36)amide (0.1-10 μM; 24 h) retains cell viability and decreases apoptosis against Streptozotocin (STZ; 1 μM) in INS‐1 cells. has not independently confirmed the accuracy of these methods. They are for reference only.Cell Viability Assay
体内研究(In Vivo)	GLP-1(32-36)amide (1 μmol/kg; i.p. once daily for 21 d) protects islet from damage, inhibits weight gain, and relieves symptoms of polydipsia in diabetic mice. GLP-1(32-36)amide (1 μmol/kg; a single i.p.) slightly reduces the mean glucose lever at 30 min after the challenge of glucose in normal mice. GLP-1(32-36)amide (50-70 nmol/kg/d; infusion for 12-16 weeks) prevents the development of diet-induced obesity and hepatic steatosis in high fat-fed mice. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
SequenceShortening	LVKGR-NH2
Sequence	Leu-Val-Lys-Gly-Arg-NH2
参考文献	[1]. Elahi D, et, al. GLP-1(32-36)amide, a novel pentapeptide cleavage product of GLP-1, modulates whole body glucose metabolism in dogs. Peptides. 2014 Sep;59:20-4. [2]. Sun L, et, al. Novel Pentapeptide GLP-1 (32-36) Amide Inhibits β-Cell Apoptosis In Vitro and Improves Glucose Disposal in Streptozotocin-Induced Diabetic Mice. Chem Biol Drug Des. 2015 Dec;86(6):1482-90.

溶解度数据	In Vitro: DMSO : 250 mg/mL (438.04 mM; Need ultrasonic)配制储备液

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