PEN (human)
目录号: PL05951 纯度: ≥99%
CAS No. :597578-70-6
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中文名称
PEN (human)
英文名称
PEN (human)
英文别名
PEN (human);pro-SAAS (221-242);L-Valine, L-alanyl-L-alanyl-L-α-aspartyl-L-histidyl-L-α-aspartyl-L-valylglycyl-L-seryl-L-α-glutamyl-L-leucyl-L-prolyl-L-prolyl-L-α-glutamylglycyl-L-valyl-L-leucylglycyl-L-alanyl-L-leucyl-L-leucyl-L-arginyl-
Cas No.
597578-70-6
分子式
C97H159N27O32
分子量
2215.46
包装储存
Sealed storage, away from moisture and light, under nitrogenPowder -80°C 2 years;-20°C 1 ye
产品详情
PEN (human) 是由 ProSAAS 原蛋白衍生而来的最丰富的下丘脑神经肽之一,是 GPR83 的内源性配体。
生物活性
PEN (human), one of the most abundant hypothalamic neuropeptide and derived from the proprotein ProSAAS, is an endogenous ligand of GPR83.
性状
Solid
体外研究(In Vitro)
Mouse PEN (mPEN) and rat PEN (rPEN) only differ by one residue at the N-terminal end, whereas human PEN (hPEN) is more divergent and has the sequence PEG instead of PEN.
PEN binds and activates a GPCR in the brain.
has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Sealed storage, away from moisture and light, under nitrogenPowder -80°C 2 years;-20°C 1 ye
SequenceShortening
AADHDVGSELPPEGVLGALLRV
参考文献
[1]. Seshat M Mack, et al. Neuropeptide PEN and Its Receptor GPR83: Distribution, Signaling, and Regulation. ACS Chem Neurosci. 2019 Apr 17;10(4):1884-1891.
[2]. Ivone Gomes, et al. Identification of GPR83 as the receptor for the neuroendocrine peptide PEN. Sci Signal. 2016 Apr 26;9(425):ra43.
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