Chemerin-9 (149-157) (TFA)||-陌孚医药/Medlife

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Chemerin-9 (149-157) (TFA)

目录号: PL05908 纯度: ≥99%

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中文名称	Chemerin-9 (149-157) (TFA)
英文名称	Chemerin-9 (149-157) (TFA)
包装储存	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year

产品详情	Chemerin-9 (149-157) TFA 是趋化因子样受体1 (CMKLR1) 的有效激动剂。Chemerin-9 (149-157) TFA 具有抗炎活性。Chemerin-9 (149-157) TFA 刺激 Akt 和 ERK 的磷酸化以及活性氧的产生。Chemerin-9 (149-157) TFA 改善 Aβ_1-42 诱导的记忆障碍。Chemerin-9 (149-157) TFA 调节免疫反应、脂肪细胞分化和糖代谢。
生物活性	Chemerin-9 (149-157) TFA is a potent agonist of chemokine-like receptor 1 (CMKLR1) . Chemerin-9 (149-157) TFA has anti-inflammatory activity. Chemerin-9 (149-157) TFA stimulates phosphorylation of Akt and ERK as well as ROS production. Chemerin-9 (149-157) TFA ameliorates Aβ 1-42 -induced memory impairmen. Chemerin-9 (149-157) TFA regulates immune responses, adipocyte differentiation, and glucose metabolism.
性状	Solid
体外研究(In Vitro)	Chemerin-9 (149-157) TFA (0.1 nM; 24 h; cardiac fibroblasts) stimulates migration in cardiac fibroblasts and stimulates phosphorylation of Akt and ERK as well as ROS production. has not independently confirmed the accuracy of these methods. They are for reference only.Western Blot Analysis
体内研究(In Vivo)	Chemerin-9 (149-157) TFA (0.2 mg/kg; i.p.; daily, for 42 days) alleviates glucose intolerance and IR in PDM mice. Chemerin-9 (149-157) TFA (7.7? μg /kg; i.h.; daily, for 28 days) has anti-inflammatory and anti-angiogenic effects in ApoE mice and protects the abdominal aorta from MMP damage. Chemerin-9 (149-157) TFA (8 μg/kg; ICV; daily; for 14 d; male Kunming mice) ameliorates Aβ 1-42 -induced memory impairment. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
SequenceShortening	YFPGQFAFS
参考文献	[1]. Tu J, et, al. Regulatory effect of chemerin and therapeutic efficacy of chemerin 9 in pancreatogenic diabetes mellitus. Mol Med Rep. 2020 Mar;21(3):981-988. [2]. Chen S, et, al. Chemerin-9 Attenuates Experimental Abdominal Aortic Aneurysm Formation in ApoE-/- Mice. J Oncol. 2021 Apr 17;2021:6629204.

溶解度数据	In Vitro: H₂O : 100 mg/mL (84.95 mM; Need ultrasonic)配制储备液

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