PACAP-38 (31-38), human, mouse, rat|138764-85-9|-陌孚医药/Medlife

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PACAP-38 (31-38), human, mouse, rat

目录号: PL05909 纯度: ≥98%

CAS No. :138764-85-9

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中文名称	PACAP-38 (31-38), human, mouse, rat
英文名称	PACAP-38 (31-38), human, mouse, rat
英文别名	TYR-LYS-GLN-ARG-VAL-LYS-ASN-LYS-NH2;H-TYR-LYS-GLN-ARG-VAL-LYS-ASN-LYS-NH2;PACAP 1-38,PituitaryAdenylateCyclase-ActivatingPolypeptide1-38;PACAP-38 (31-38) (human, chicken, mouse, ovine, porcine, rat);PITUITARY ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE-38 (31-38) (HUMAN, CHICKEN, MOUSE, OVINE, PORCINE, RAT);PACAP 1-38;PHE-THR-ASP-SER-TYR-SER-ARG-TYR-ARG-LYS-GLN-MET-ALA-VAL-LYS-LYS-TYR-LEU-ALA-ALA-VAL-LEU-NH2: FTDSYSRYRKQMAVKKYLAAVL0NH2;PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE 1-38;PACAP-38 (31-38), human, mouse, rat
Cas No.	138764-85-9
分子式	C₄₇H₈₃N₁₇O₁₁
分子量	1062.27
包装储存	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year

产品详情	PACAP-38 (31-38), human, mouse, rat 是一种 PAC₁ 受体激活剂，增加 α-分泌酶活性。PACAP-38 (31-38), human, mouse, rat 升高胞浆 Ca²⁺，增加细胞外调节激酶 (ERK) 和表皮生长因子受体 (EGFR) 的增殖和磷酸化。PACAP-38 (31-38), human, mouse, rat 对交感神经 NPY 和儿茶酚胺的产生具有强效、持续的刺激作用。PACAP-38 (31-38), human, mouse, rat 可用于神经营养和神经保护研究。
生物活性	PACAP-38 (31-38), human, mouse, rat is a PAC 1 receptor activator and increases the α-secretase activity. PACAP-38 (31-38), human, mouse, rat elevates cytosolic Ca, increases proliferation and increases phosphorylation of extracellular regulates kinase (ERK) and the epidermal growth factor receptor (EGFR). PACAP-38 (31-38), human, mouse, rat demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production. PACAP-38 (31-38), human, mouse, rat can be used for neurotrophic and neuroprotective research.
性状	Solid
体外研究(In Vitro)	PACAP-38 (31-38), human, mouse, rat (100 nM; 2 min; NCI-H838 cells) induces EGFR, HER2 and ERK tyrosine phosphorylation. PACAP-38 (31-38), human, mouse, rat (100 nM; 30 min; NCI-H838 cells) induces EGFR tyrosine phosphorylation with generates ROS and increases ROS levels by 51%. PACAP-38 (31-38), human, mouse, rat (10 nM; 48 h) stimulates the growth of NCI-H838 cells. PACAP-38 (31-38), human, mouse, rat (300 nM; 4 h) stimulates generation of APPsα in neural cells. PACAP-38 (31-38), human, mouse, rat (0.01-10 nM; HEK 293 cells) stimulates neural cells express endogenous PAC1 receptors by cAMP accumulation and by an increase in cytosolic free calcium and induces elevation of the intracellular Ca concentration in a dose-dependent manner with an EC50 value of 0.81 nM. PACAP-38 (31-38), human, mouse, rat (0.01 nM; 48 h) elicits potent and efficacious
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
SequenceShortening	YKQRVKNK-NH2
Sequence	Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2
参考文献	[1]. Moody TW, et, al. PAC1 regulates receptor tyrosine kinase transactivation in a reactive oxygen species-dependent manner. Peptides. 2019 Oct;120:170017. [2]. Kojro E, et, al. The neuropeptide PACAP promotes the alpha-secretase pathway for processing the Alzheimer amyloid precursor protein. FASEB J. 2006 Mar;20(3):512-4.

溶解度数据	In Vitro: H₂O : 100 mg/mL (94.14 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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