Small Cardioactive Peptide B (SCPB)
目录号: PL05862 纯度: ≥98%
CAS No. :84746-43-0
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中文名称
Small Cardioactive Peptide B (SCPB)
英文名称
Small Cardioactive Peptide B (SCPB)
英文别名
Small cardioactive peptide B;CARDIOACTIVE PEPTIDE B (SMALL);MET-ASN-TYR-LEU-ALA-PHE-PRO-ARG-MET-NH2;SCPB;SCPB Cardioactive Peptide B (small);H-MET-ASN-TYR-LEU-ALA-PHE-PRO-ARG-MET-NH2;MET-ASN--LEU-ALA-PHE-PRO-ARG-MET (MET-ASN-TYR-LEU-ALA-PHE-PRO-ARG-MET AMIDE);MET-ASN-TYR-LEU-ALA-PHE-PRO-ARG-MET AMIDE;MNYLAFPRM-NH2
Cas No.
84746-43-0
分子式
C52H80N14O11S2
分子量
1141.41
包装储存
Sealed storage, away from moisture and light, under nitrogenPowder -80°C 2 years;-20°C 1 ye
产品详情
Small Cardioactive Peptide B (SCPB) 是一种神经活性肽,刺激心脏和鳃组织的颗粒组分中的腺苷酸环化酶 (adenylate cyclase) 活性,EC50 分别为 0.1 和 1.0 μM。
生物活性
Small Cardioactive Peptide B (SCP B ), a neurally active peptide, stimulates adenylate cyclase activity in particulate fractions of both heart and gill tissues with EC 50 s of 0.1 and 1.0 μM, respectively.
性状
Solid
IC50 & Target[1][2]
EC50: 0.1 μM (adenylate cyclase, in heart tissues), 1.0 μM (adenylate cyclase, in gill tissues)
体外研究(In Vitro)
Small cardioactive peptide B (SCPB) is a neurally active peptide endogenous to Aplysia . Small cardioactive peptide B (SCPB) possesses cardioexcitatory effects in Aplysia and reported a threshold concentration of 0.01 nM for both native and synthetic Small cardioactive peptide B (SCPB) stimulated effects on the isolated heart. Effects of Small Cardioactive Peptide B (SCPB) on the physiology of the isolated heart and gill preparations from the mollusc Aplysia californica were examined. In addition, the effects of Small Cardioactive Peptide B (SCPB) and FMRFamide (Phe-Met-Arg-Phe-NH2) on adenylate cyclase activity are compared in particulate fractions of heart and gill tissues, respectively. Small Cardioactive Peptide B (SCPB) is found to exert dose-dependent, reversible changes in cardiac activity wh
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Sealed storage, away from moisture and light, under nitrogenPowder -80°C 2 years;-20°C 1 ye
SequenceShortening
MNYLAFPRM-NH2
Sequence
Met-Asn-Tyr-Leu-Ala-Phe-Pro-Arg-Met-NH2
参考文献
[1]. Cawthorpe DR, et al. The effects of small cardioactive peptide B on the isolated heart and gill of Aplysia californica. Can J Physiol Pharmacol. 1985 Aug;63(8):918-24.
溶解度数据
In Vitro: H2O : 50 mg/mL (43.81 mM; Need ultrasonic)配制储备液
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1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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