ACTH (1-17) (TFA)||(α1-17-ACTH TFA)-陌孚医药/Medlife

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ACTH (1-17) (TFA) (Synonyms: α1-17-ACTH TFA)

目录号: PL05873 纯度: ≥99%

商品编号	规格	价格	会员价
PL05873-1mg	1mg	¥1607.27	请登录
PL05873-5mg	5mg	¥5563.64	请登录
PL05873-10mg	10mg	¥8036.36	请登录
PL05873-50mg	50mg	询价	询价
PL05873-100mg	100mg	询价	询价

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中文名称	ACTH (1-17) (TFA)
英文名称	ACTH (1-17) (TFA)
包装储存	Sealed storage, away from moisture and lightPowder -80°C 2 years；-20°C 1 year

产品详情	ACTH (1-17) TFA 是促肾上腺皮质激素类似物，是一种有效的人黑皮素受体 (human melanocortin 1 (MC1) receptor) 激动剂，K_i 值为 0.21 nM。
生物活性	ACTH (1-17) TFA, an adrenocorticotropin analogue, is a potent human melanocortin 1 (MC1) receptor agonist with a K i of 0.21 nM.
性状	Solid
IC50 & Target[1][2]	MC1R
体外研究(In Vitro)	ACTH (1-17) TFA is a potent agonist at the hMC1R. ACTH (1-17) shows high affinity for the hMC1R with a Ki value of 0.21±0.03 nM which is slightly higher than that of 0.13±0.005 nM for alpha-MSH. ACTH (1-17) induces a slight and not significant increase in growth hormone secretion even when micromolar concentrations of the peptide are employed in rat pituitary cultures. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Inhibition of DNA labeling is noted when the ACTH (1-17) is administered at 2 hr after the beginning of the daily dark span when nocturnal animals become active. When administered at this circadian stage, the larger dose in particular is associated with an inhibition of DNA labeling lasting for 24 hr. The inhibitory effect is much shorter when the same dose is injected 4 hr earlier. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisture and lightPowder -80°C 2 years；-20°C 1 year
SequenceShortening	SYSMEHFRWGKPVGKKR
Sequence	Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg
参考文献	[1]. Tsatmali M et al. ACTH1-17 is a more potent agonist at the human MC1 receptor than alpha-MSH. Cell Mol Biol (Noisy-le-grand). 1999 Nov;45(7):1029-34. [2]. Ceda GP, et al. The effects of ACTH (1-17) on GH secretion in vitro. Horm Metab Res. 1987 Aug;19(8):361-3. [3]. Walker WV, et al. Effect of an adrenocorticot

溶解度数据	In Vitro: H₂O : 100 mg/mL (45.30 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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