Urotensin I TFA||(Catostomus urotensin I TFA)-陌孚医药/Medlife

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Urotensin I TFA (Synonyms: Catostomus urotensin I TFA)

目录号: PL05872 纯度: ≥98%

商品编号	规格	价格	会员价	是否有货	数量
PL05872-500μg	500μg	¥4203.64	请登录

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中文名称	Urotensin I TFA
英文名称	Urotensin I TFA
包装储存	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year

产品详情	Urotensin I (Catostomus urotensin I) TFA 是一种类 CRF 样肽，可作为 CRF 受体激动剂，在细胞实验中，对人 CRF₁，CRF₂ 和大鼠 CRF_2α 受体的 pEC₅₀ 值分别为 11.46，9.36 和 9.85，对 hCRF₁，rCRF_2α 和 mCRF_2β 受体的 K_i 值分别为 0.4，1.8 和 5.7 nM。
生物活性	Urotensin I (Catostomus urotensin I) TFA, a CRF-like neuropeptide, acts as an agonist of CRF receptor with pEC 50 s of 11.46, 9.36 and 9.85 for human CRF 1 , human CRF 2 and rat CRF 2α receptors in CHO cells, and K i s of 0.4, 1.8, and 5.7 nM for hCRF 1 , rCRF 2α and mCRF 2β receptors, respectively.
性状	Solid
IC50 & Target[1][2]	pEC50: 11.46 (human CRF1, CHO cells), 9.36 (human CRF2, CHO cells), 9.85 (rat CRF2α, CHO cells) Ki: 0.4 nM (hCRF1, cell assay), 1.8 nM (rCRF2α, cell assay), and 5.7 nM (mCRF2β, cell assay)
体外研究(In Vitro)	Urotensin I is 2-3 times more potent than CRF or sauvagine in stimulating ACTH release from a superfused goldfish anterior pituitary cell column. Rat tail artery strips were incubated in the presence of 4 x 10(-3) M theophylline and Urotensin I (UI). At the concentrations of 1.50, 7.50 mU/ml but not of 0.75 mU/ml Urotensin I, the content of cAMP increased significantly. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Intraperitoneal injections of urotensin I, a CRF-like neuropeptide isolated from the caudal neurosecretory system of the teleost Catostomus commersoni, ovine CRF and sauvagine all produced significant increases in circulating levels of plasma cortisol in goldfish in which endogenous ACTH secretion was suppressed with betamethasone. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
SequenceShortening	NDDPPISIDLTFHLLRNMIEMARIENEREQAGLNRKYLDEV-NH2
Sequence	Asn-Asp-Asp-Pro-Pro-Ile-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Asn-Met-Ile-Glu-Met-Ala-Arg-Ile-Glu-Asn-Glu-Arg-Glu-Gln-Ala-Gly-Leu-Asn-Arg-Lys-Tyr-Leu-Asp-Glu-Val-NH2
参考文献	[1]. Smart D, et al. Characterisation using microphysiometry of CRF receptor pharmacology. Eur J Pharmacol. 1999 Aug 27;379(2-3):229-35. [2]. Reul JM, et al. Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression. Curr Opin Pharmacol. 2002 Feb;2(1):23-33. [3]. Fryer J, et al. Urotensin I, a CRF-l

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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