Gap19 TFA||-陌孚医药/Medlife

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Gap19 TFA

目录号: PL05813 纯度: ≥96%

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PL05813-50mg	50mg	询价	询价
PL05813-100mg	100mg	询价	询价

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中文名称	Gap19 TFA
英文名称	Gap19 TFA
包装储存	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year

产品详情	Gap19 TFA 是一种衍生自 Cx43 细胞质环 (CL) 九个氨基酸的肽，一种有效的，选择性连接蛋白 43 (Cx43) 半通道阻滞剂。Gap19 TFA 可以防止 C 末端 (CT) 与 CL 的分子内相互作用。Gap19 TFA 不阻断 GJ 通道或 Cx40/pannexin-1 半通道。Gap19 TFA 对心肌具有保护作用。
生物活性	Gap19 TFA, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 TFA inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 TFA is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 TFA has protective effects against myocardial.
性状	Solid
IC50 & Target[1][2]	Cx43 Hemichannel
体外研究(In Vitro)	Gap19 TFA (250 μM; for 30 min ) decreases mitochondrial potassium uptake. Gap19 TFA (400 μM) inhibits unitary hemichannel currents in HeLa-Cx43 cells. Gap19 TFA (100 μM) inhibits hemichannel unitary currents in ventricular cardiomyocytes. Gap19 TFA (250 μM, 30 min) protects against myocardial ischemia/reperfusion injury in vitro and in vivo. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Gap19 TFA (iv; 25 mg/kg; 10 min before ligation) significantly reduces the infarct size by approximately one-fifth. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57/BL6 mice
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
SequenceShortening	KQIEIKKFK
参考文献	[1]. Boengler K, et al. Connexin 43 impacts on mitochondrial potassium uptake. Front Pharmacol. 2013 Jun 6;4:73. [2]. Wang N, et al. Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury. Basic Res Cardiol. 2013 Jan;108(1):309.

溶解度数据	In Vitro: DMSO : 100 mg/mL (78.40 mM; Need ultrasonic)H₂O : 100 mg/mL (78.40 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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