Insulin(cattle)|11070-73-8|(牛胰岛素)-陌孚医药/Medlife

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Insulin(cattle) (Synonyms: 牛胰岛素)

目录号: PL05818 纯度: ≥98%

CAS No. :11070-73-8

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中文名称	Insulin(cattle)
中文别名	牛胰岛素;(3S)-四氢呋喃-3-甲胺;苯并二氢吡喃-8-磺酰氯;牛胰岛素 ,BR;牛胰岛素 Insulin from bovine;胰岛素;胰岛素(牛);胰岛素（牛） USP标准品;重组人胰岛素;胰岛素(猪)成分标准物质;牛胰岛;胰岛素来源于牛胰腺;牛重组;胰岛素(牛/牛重组/人);Insulin 牛胰岛素
英文名称	Insulin(cattle)
英文别名	insulin from bovine pancreas;Insulin;Insulin (bovin);Insulin (Porcine);insulin bovine;insulin human;insulin hybri-max from bovine pancreas;ProMaxx;insulin(ox);Insulin beef;bovineinsulin;Insulin (cattle);Insulinfrombovine;INSULIN (powder);27USP U;27USP U/MG;Insulin(cattle)
Cas No.	11070-73-8
分子式	C₂₅₄H₃₇₇N₆₅O
分子量	5733.49
包装储存	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year

产品详情	Insulin cattle (Insulin from bovine pancreas) 是在胰腺 β 细胞中产生的两链多肽激素。Insulin cattle 在很多哺乳动物细胞培养体系中用作生长因子。
生物活性	Insulin cattle (Insulin from bovine pancreas) is a two-chain polypeptide hormone produced in vivo in the pancreatic β cells. Insulin cattle has often been used as growth supplement in culturing cells.
性状	Solid
体外研究(In Vitro)	Two-chain polypeptide hormone produced by the β-cells of pancreatic islets. The α and β chains are joined by two interchain disulfide bonds. The α chain contains an intrachain disulfide bond. Insulin regulates glucose uptake into muscle and fat cells by recruiting membrane glucose transporter Glut-4 to cell surface. Insulin cattle has often been used as growth supplement in culturing cells at the concentration ranging from 1 to 10 μg/mL of medium. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
SequenceShortening	FVNQHLCGSHLVEALYLVCGERGFFYTPKA. GIVEQCCASVCSLYQLENYCN (Disulfide bridge: Cys7-Cys7, Cys19-Cys20, Cys6-Cys11)
Sequence	Phe-Val-Asn-Gln-His-Leu-Cys-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cys-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala. Gly-Ile-Val-Glu-Gln-Cys-Cys-Ala-Ser-Val-Cys-Ser-Leu-Tyr-Gln-Leu-Glu-Asn-Tyr-Cys-Asn (Disulfide bridge: Cys7-Cys7, Cys19-Cys20, Cys6
参考文献	[1]. Yousefi R, et al. Aspirin-mediated acetylation induces structural alteration and aggregation of bovine pancreaticinsulin. J Biomol Struct Dyn. 2016;34(2):362-75.

溶解度数据	In Vitro: H₂O : 10 mg/mL (1.74 mM; ultrasonic and warming and adjust pH to 3 with HCl and heat to 60°C)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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