WKYMVM-NH2 TFA
目录号: PL05812 纯度: ≥98%
CAS No. :1435781-74-0
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中文名称
WKYMVM-NH2 TFA
英文名称
WKYMVM-NH2 TFA
英文别名
WKYMVM-NH2 TFA
Cas No.
1435781-74-0
包装储存
Sealed storage, away from moisturePowder -80°C 2 years;-20°C 1 year
产品详情
WKYMVM-NH2 TFA 是有效的 N-甲酰肽受体 FPR1 和 FPRL1/2 的激动剂,同时可以激活一些白细胞效应功能,如趋化性、激活补体受体-3 及 NADPH 氧化酶。
生物活性
WKYMVM-NH2 TFA is a potent N-formyl peptide receptor (FPR1) and FPRL1/2 agonist, also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and activation of the NADPH oxidase.
性状
Solid
体外研究(In Vitro)
WKYMVM-NH2 TFA (10-1000?nM; 24?hours) induces Caco-2 cells proliferation.
has not independently confirmed the accuracy of these methods. They are for reference only.Cell Proliferation Assay
体内研究(In Vivo)
WKYMVM-NH2 TFA (8?mg/kg; six times; for 5 days) ameliorates DSS-induced ulcerative colitis.
WKYMVM-NH2 TFA affects cytokine (IL-17, IFN-γ, IL-6, IL-1β and TNF-α) profiles in the DSS colitis model.
has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Sealed storage, away from moisturePowder -80°C 2 years;-20°C 1 year
SequenceShortening
WKYMVM-NH2
参考文献
[1]. Christophe T, et al. The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2. J Biol Chem. 2001 Jun 15;276(24):21585-93.
[2]. Christophe T, et al. Phagocyte activation by Trp-Lys-Tyr-Met-Val-Met, acting through FPRL1/LXA4R, is not affected by lipoxin A4. Scand J Immunol. 2002 Nov;56(5):470-6.
溶解度数据
In Vitro: H2O : 12.5 mg/mL (12.88 mM; Need ultrasonic)配制储备液
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1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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