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| 中文名称 |
GP(33-41) TFA
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| 英文名称 |
GP(33-41) TFA
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| 包装储存 |
Sealed storage, away from moisture and lightPowder -80°C 2 years；-20°C 1 year
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| 产品详情 |
GP(33-41) TFA 是一种由 9 个氨基酸残基组成的多肽，它是淋巴细胞性脉络丛脑膜炎病毒 GP1 抗原决定基中的最佳序列。GP(33-41) TFA 能够上调 RMA-S (Db Kb) 细胞表面 H-2Db 分子，SC50 值为 344 nM。
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| 生物活性 |
GP(33-41) TFA, a 9-aa-long peptide, is the optimal sequence of the GP1 epitope of lymphocytic choriomeningitis virus. GP(33-41) TFA can upregulate H-2D molecules at the RMA-S (Db Kb) cell surface with a SC 50 of 344 nM.
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| 性状 |
Solid
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| 体外研究(In Vitro) |
GP(33-41) TFA sensitizes MC57 and T2-D cells to lysis with ED50s of 0.9±0.6 and 2.5±0.7 nM. The interaction between T cell receptors (TCR) and peptide-major histocompatibility complex (pMHC) antigens can lead to varying degrees of agonism (T cell activation), or antagonism. The P14 TCR recognises the lymphocytic choriomeningitis virus (LCMV)-derived peptide, GP(33-41) (KAVYNFATC), presents in the context of H-2D. has not independently confirmed the accuracy of these methods. They are for reference only.
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
Sealed storage, away from moisture and lightPowder -80°C 2 years；-20°C 1 year
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| 参考文献 |
[1]. Gairin JE, et al. Optimal lymphocytic choriomeningitis virus sequences restricted by H-2Db major histocompatibility complex class I molecules and presented to cytotoxic T lymphocytes. J Virol. 1995 Apr;69(4):2297-305.[2]. Boulter JM, et al. Potent T cell agonism mediated by a very rapid TCR/pMHC interaction. Eur J Immunol. 2007 Mar;37(3):798-806.
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| 溶解度数据 |
In Vitro: H2O : 1.82 mg/mL (1.61 mM; ultrasonic and adjust pH to 4 with HCl)配制储备液
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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。
2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。
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