Kisspeptin-10, human TFA||(亲吻促动素-10三氟乙酸盐(人源))-陌孚医药/Medlife

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Kisspeptin-10, human TFA (Synonyms: 亲吻促动素-10三氟乙酸盐(人源))

目录号: PL05779 纯度: ≥98%

商品编号	规格	价格	会员价
PL05779-1mg	1mg	¥1483.64	请登录
PL05779-5mg	5mg	¥5069.09	请登录
PL05779-10mg	10mg	询价	询价
PL05779-50mg	50mg	询价	询价

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中文名称	Kisspeptin-10, human TFA
英文名称	Kisspeptin-10, human TFA
包装储存	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year

产品详情	Kisspeptin-10, human TFA 是一种有效的血管收缩剂和血管生成抑制剂。Kisspeptin-10, human TFA 通过其受体 GPR54 来抑制肿瘤转移作用。Kisspeptin-10-GPR54 系统在胚胎肾脏发育中起重要作用。Kisspeptin-10/GPR54 信号通过 NFATc4 介导的 BMP2 表达来诱导成骨细胞分化。
生物活性	Kisspeptin-10, human TFA is a potent vasoconstrictor and inhibitor of angiogenesis. Kisspeptin-10, human TFA acts as a tumor metastasis suppressor via its receptor GPR54. Kisspeptin-10-GPR54 system plays an important role in embryonic kidney development. Kisspeptin-10/GPR54 signaling induces osteoblast differentiation via NFATc4-mediated BMP2 expression.
性状	Solid
IC50 & Target[1][2]	GPR54 Angiogenesis
体外研究(In Vitro)	Kisspeptin-10 (KP-10) and its receptor GPR54 are key components in the regulation of GnRH secretion in humans and other mammals. Kisspeptin-10 protein binds to GPR54. Activation of Kisspeptin-10 suppresses pulmonary human melanoma and Kisspeptin-10 is a metastasis suppressor in breast cancer cells. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Intravenous infusion of kisspeptin-10 (7.5, 35, and 100 nM) induces a dose-dependent increase in LH secretion. The stimulatory effect of kisspeptin-10 (100 n nM) on LH secretion is blocked by the GnRH antagonist cetrorelix, precluding a singular action on gonadotropes. Kisspeptin-10 inhibits angiogenesis in vivo. Kp-10 inhibits tumor growth in SCID mice xenografted with human prostate cancer cells (PC-3) through inhibiting tumor angiogenesis. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
SequenceShortening	YNWNSFGLRF-NH2
参考文献	[1]. Son HE, et al. Kisspeptin-10 (KP-10) stimulates osteoblast differentiation through GPR54-mediated regulation of BMP2 expression and activation. Sci Rep. 2018 Feb 1;8(1):2134.

溶解度数据	In Vitro: DMSO : 100 mg/mL (70.60 mM; Need ultrasonic)H₂O : 4 mg/mL (2.82 mM; Need ultrasonic)配制储备液

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