Microcystin-LR|101043-37-2|(Cyanoginosin-LR; MC-LR; Toxin T 17 (Microcystis aeruginosa))-陌孚医药/Medlife

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Microcystin-LR (Synonyms: Cyanoginosin-LR; MC-LR; Toxin T 17 (Microcystis aeruginosa))

目录号: PL05750 纯度: ≥95%

CAS No. :101043-37-2

商品编号	规格	价格	会员价	是否有货	数量
PL05750-100μg(0.5mM*200μLinEthanol)	100μg(0.5mM*200μLinEthanol)	¥4512.73	请登录
PL05750-50μg(0.5mM*100μLinEthanol)	50μg(0.5mM*100μLinEthanol)	¥2658.18	请登录

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中文名称	Microcystin-LR
中文别名	微囊藻毒素LR;微囊藻毒素(LR亚型);微囊藻毒素-LR;微囊藻毒素LR 标准品;微囊藻毒素;快速死亡因子;微囊藻毒素-LR 溶液;微囊藻毒素LR标准品
英文名称	Microcystin-LR
英文别名	Cyclo[2,3-didehydro-N-methylalanyl-D-alanyl-L-leucyl-(3S)-3-methyl-D-b-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-g-glutamyl];5-L-Arginine-microcystin LA;Microcystin LR;Microcystin-LR;Microcystin-LR solution;5-L-Arginine-cyanoginosin;akerstox;C05371;CYANOGINOSIN-LR;cyclo(D-Ala-L-Leu-D-MeAsp-L-Arg-Adda-D-Glu-Mdha);MC-LR;MCYST-LR;microcystin-a;Toxin T 17 (Microcystis aeruginosa);TOXIN,BLUE-GREENALGA;toxin-lr;Microcystin LR 95%;Cyanoginosin LR;Microcystis aeruginosa toxin;C49H74N10O12;EQ8332842Y;Microcystin-LR, Microcystis aeruginosa;Toxin I (Microcystis aeruginosa);5-L-Argininecyanoginosin LA;toxin I, cyanobacterium
Cas No.	101043-37-2
分子式	C₄₉H₇₄N₁₀O₁₂
分子量	995.17
包装储存	Please store the product under the recommended conditions in the Certificate of Analysis.

产品详情	Microcystin-LR 是蛋白磷酸酶 1 型和 2A 型 (PP1/2A) 的有效抑制剂，其 IC₅₀ 值分别为 1.7 nM，0.04 nM。
生物活性	Microcystin-LR is a potent inhibitor of type 1 and type 2A protein phosphatases (PP1 and PP2A), with IC 50 s of 1.7 nM and 0.04 nM, respectively.
性状	Liquid
IC50 & Target[1][2]	IC50: 1.7 nM (PP1), 0.04 nM (PP2A).
体外研究(In Vitro)	Microcystins are toxic molecules produced by cyanobacterial blooms due to water eutrophication. Microcystin-LR proves to be a potent inhibitor of type 1 (IC50=1.7 nM) and type 2A (IC50= 0.04 nM) protein phosphatases. Microcystin-LR inhibits the activity of both type 1 and type 2A phosphatases >10-fold more potently than okadaic acid under the same conditions. Type 2A protein phosphatases in dilute mammalian cell extracts are found to be completely inhibited by 0.5 nM microcystin-LR while type 1 protein phosphatases are only slightly affected at this concentration. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
SequenceShortening	ADALD-{Bas}-R-{Oaa}-D-{Ggu}
参考文献	[1]. Honkanen RE, et al. Characterization of microcystin-LR, a potent inhibitor of type 1 and type 2A protein phosphatases. J Biol Chem. 1990 Nov 15;265(32):19401-4. [2]. Lone Y, et al. Microcystin-LR Induced Immunotoxicity in Mammals. J Toxicol. 2016:8048125.

溶解度数据	In Vitro: Ethanol : 0.5 mg/mL (0.50 mM; Need ultrasonic)

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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