GLP-1(7-37)|106612-94-6|(人胰高血糖素样肽-1)-陌孚医药/Medlife

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GLP-1(7-37) (Synonyms: 人胰高血糖素样肽-1)

目录号: PL05743

CAS No. :106612-94-6

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中文名称	GLP-1(7-37)
中文别名	人胰高血糖素样肽-1;醋酸人胰高血糖素样肽;醋酸人胰高血糖素样肽-1;醋酸人胰高血糖素样肽-1 (7-37) GLP-1 (7-37) Acetate;醋酸人胰高血糖素样肽-1(7-37) GLP-1(7-37)Acetate;胰高血糖素样肽;人胰高血糖素样肽;人胰高血糖素样肽-1(7-37);醋酸人胰高血糖素样肽-1 GLP-1(7-37)
英文名称	GLP-1(7-37)
英文别名	Human GLP-1 (7-37);7-37-Glucagon-like peptide I (human);Insulinotropin (human);Peptide GLP-1 (human glucose-lowering peptide-1);GLP-1 (7-37);GLP-1 (7-37) (human, bovine, guinea pig, mouse, rat);GLP-1(7-37) Acetate;GLP-1,7-37;GLUCAGON-LIKE PEPTIDE 1 (7-37);HAEGTFTSDVSSYLEGQAAKEFIAWLVKGRG;H-HIS-ALA-GLU-GLY-THR-PHE-THR-SER-ASP-VAL-SER-SER-TYR-LEU-GLU-GLY-GLN-ALA-ALA-LYS-GLU-PHE-ILE-ALA-TRP-LEU-VAL-LYS-GLY-ARG-GLY-OH;Tesamorelin Acetate;Glucagon-Like Peptide 1;HIS-ALA-GLU-GLY-THR-PHE-THR-SER-ASP-VAL-SER-SER-TYR-LEU-GLU-GLY-GLN-ALA-ALA-LYS-GLU-PHE-ILE-ALA-TRP-LEU-VAL-LYS-GLY-ARG-GLY;HuMan GLP-1;insulinotropin;Preproglucagon 78-108;PREPROGLUCAGON 78-108 HUMAN;Tglp-1;Glp-I (7-37);GLP-1 (7-37) (HUMAN);7-37-Glucagon-likepeptide;GLP-1(7-37)
Cas No.	106612-94-6
分子式	C₁₅₁H₂₂₈N₄₀O₄₇
分子量	3355.67
包装储存	Sealed storage, away from moisture and lightPowder -80°C 2 years；-20°C 1 year

产品详情	GLP-1(7-37) 是一种肠道胰岛素激素，可以增强葡萄糖诱导的胰岛素分泌。
生物活性	GLP-1(7-37) is an intestinal insulinotropic hormone that augments glucose induced insulin secretion.
性状	Solid
体内研究(In Vivo)	GLP-1(7-37) (0.5, 5 or 50 pmol/min/kg) infused during the second hour of a 2-hour 11-mM hyperglycemic clamp produces a dose-related enhancement of the glucose-stimulated increase in plasma insulin concentration and an increased rate of glucose infusion in rats. Infusion of GLP-1(7-37) (5 pmol/min/kg) from 1 hour through 7 hours produces a sustained increase in plasma insulin concentration relative to levels in rats infused with vehicle in rats with maintained glucose concentration at 11 mM. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisture and lightPowder -80°C 2 years；-20°C 1 year
SequenceShortening	HAEGTFTSDVSSYLEGQAAKEFIAWLVKGRG
Sequence	His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly
参考文献	[1]. Sarrauste de Menthiere, C. et al. Structural requirements of the N-terminal region of GLP-1-[7-37]-NH2 for receptor interaction and cAMP production. European journal of medicinal chemistry 39, 473-480, doi:10.1016/j.ejmech.2004.02.002 (2004). [2]. Hargrove DM, et al. Glucose-dependent action of glucagon-like peptide-1 (7-37) in vivo during short- or long-term administration. Metabolism. 1995 Sep;44(9):1231-7.

溶解度数据	In Vitro: H₂O : 30 mg/mL (8.94 mM; Need ultrasonic and warming)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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