Ferric citrate|3522-50-7|(柠檬酸铁; Iron(III) citrate; Zerenex)-陌孚医药/Medlife

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Ferric citrate (Synonyms: 柠檬酸铁; Iron(III) citrate; Zerenex)

目录号: PL05715 纯度: ≥98%

CAS No. :3522-50-7

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中文名称	Ferric citrate
中文别名	柠檬酸铁;柠檬酸铁(III)水合物;柠檬酸亚铁;食用柠檬酸;枸橼酸铁;柠檬酸三铁;柠檬酸铁(III);柠檬酸铁,Ferric citrate,AR;柠檬酸铁,Ferric citrate,细胞培养级
英文名称	Ferric citrate
英文别名	ferric citrate;Ferric citrate cell culture tested;iron citrate;Iron(III) citrate;Citric acid iron;EFRRIC CITRATE;Einecs 222-536-6;Iron(III) citrate hydrate;Citricacid, iron(3+) salt (1:1) (8CI);Fe(III)-citrate complex (1:1);Zerenex;Citric acid, iron(3+) salt;Iron citrate, FeC6H5O7;iron(3+) citrate;Auryxia;63G354M39Z;Iron, (hydrogen citrato(3-))-;Iron(III)-citrate;1,2,3-Propanetricarboxylic acid, 2-hydroxy-, iron salt;FERROUS CITRATE;Citric acid, iron(3+) salt (1:1);Citric acid, iron salt;Ferric citrate [USAN];Ferric citrate (VAN);Iron 2-hydroxy-1,2,3-propanetricarboxylate;ferrum citricum;iron(i
Cas No.	3522-50-7
分子式	C₆H₅FeO₇
分子量	244.94
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情

Ferric citrate (Iron(III) citrate)，一种具有口服活性的铁补充剂，是一种有效的磷酸盐结合剂。Ferric citrate 可用于缺铁性贫血和慢性肾病 (CKD)的研究。

生物活性

Ferric citrate (Iron(III) citrate), an orally active iron supplement, is an efficacious phosphate binder. Ferric citratee can be used for iron deficiency anemia and chronic kidney disease (CKD) research.

性状

Solid

体外研究(In Vitro)

Ferric citrate (Iron(III) citrate; 1 mM; 24 hours) significantly induces CM cell death.
Ferric citrate (Iron(III) citrate; 0.1 mM, 1 mM, 2 mM; 24 hours) increases ROS generation in cardiomyocyte (CM) cells in a dose-dependent manner. has not independently confirmed the accuracy of these methods. They are for reference only.Cell Viability Assay

体内研究(In Vivo)

Here we compared the effects of Ferric citrate (25 μg/g) administration versus a mineral sufficient control diet using the Col4a3 knockout mouse model of progressive CKD and age-matched wild-type mice. Ferric citrate is given to knockout mice for four weeks beginning at six weeks of age when they had overt chronic kidney disease (CKD), or for six weeks beginning at four weeks of age when they had early CKD. Ferric citrate rescues iron deficiency and anemia in knockout mice regardless of the timing of treatment initiation, and circulating levels and bone expression of FGF23 are reduced. Ferric citrate also improves cardiac function and significantly improves survival.
Ferric citrate is an efficacious and safe phosphate binder that increases iron stores and reduces intravenous iron and erythropoietin-stimulating agent use while maintaining hemoglobin. Ferric citrate can incr

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. Yuichi Baba, et al. Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2018 Mar 1;314(3):H659-H668.
[2]. Julia B Lewis, et al. Ferric citrate controls phosphorus and delivers iron in patients on dialysis. J Am Soc Nephrol. 2015 Feb;26(2):493-503.

溶解度数据	In Vitro: H₂O : 5 mg/mL (20.41 mM; ultrasonic and warming and heat to 60°C)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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