L-Phenylalanine-d8|17942-32-4|((S)-2-Amino-3-phenylpropionic acid-d-陌孚医药/Medlife

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L-Phenylalanine-d8 (Synonyms: (S)-2-Amino-3-phenylpropionic acid-d

目录号: PL05666 纯度: ≥99%

CAS No. :17942-32-4

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中文名称	L-Phenylalanine-d8
中文别名	L-苯丙氨酸-D8氘代内标;L-苯基-d5-丙氨酸-2,3,3-d3;氘代L-苯丙氨酸
英文名称	L-Phenylalanine-d8
英文别名	L-Phenylalanine-a,b,b,2,3,4,5,6-d8;[2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrazoline-5-yl]acetic acid;[2,2-Dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid;[2,3,3,2',3',4',5',6'-2H8]-L-phenylalanine;2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1;6-(4-Chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl- 1H-pyrrolizine-5-acetic Acid;L-[2,3,4,2',3',4',5',6']-octadeuteriophenylalanine;Licofelone, ML-3000;ML 3000;L-PHENYLALANINE (D8);L-Phenyl-d5-alanine-d3;L-PHENYL-D5-ALANINE-2,3,3-D3;l-phenylalanine-phenyl-d5-2,3,3-d3;L-phenylalanine-alpha,beta,beta,2,3,4,5;L-PHENYLALANINE-ALPHA BETA BETA,2,3,4,5 6-D8;L-PHENYLALANINE-ALPHA,BETA,BETA,2,3,4,5, 6-D8, 98 ATOM % D
Cas No.	17942-32-4
分子式	C₉H₁₁NO₂
分子量	165.19
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	L-Phenylalanine-d₈ 是 L-Phenylalanine 的氘代物。L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) 是分离自大肠杆菌的必需氨基酸。L-Phenylalanine 是一种电压依赖性 α2δ 亚基 Ca2⁺ 通道拮抗剂，K_i 为 980 nM。L-Phenylalanine 是 NMDARs (K_B 573 μM) 和非 NMDARs 的甘氨酸和谷氨酸结合位点的竞争性拮抗剂。L-Phenylalanine 广泛用于食品香料和药品的生产中。
生物活性	L-Phenylalanine-d 8 is the deuterium labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
性状	Solid
IC50 & Target[1][2]	NMDA Receptor
体外研究(In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Glushakov AV, et al. Long-term changes in glutamatergic synaptic transmission in phenylketonuria. Brain. 2005 Feb;128(Pt 2):300-7. [3]. Glushakov AV, et al. L-phenylalanine

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