Quetiapine sulfoxide dihydrochloride|329218-11-3|(喹硫平亚砜双盐酸盐; Quetiapine S-oxide dihydrochloride)-陌孚医药/Medlife

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Quetiapine sulfoxide dihydrochloride (Synonyms: 喹硫平亚砜双盐酸盐; Quetiapine S-oxide dihydrochloride)

目录号: PL05627 纯度: ≥99%

CAS No. :329218-11-3

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中文名称	Quetiapine sulfoxide dihydrochloride
中文别名	2-[2-[4-(5-氧代二苯并[b,f][1,4]硫氮杂卓-11-基)-1-哌嗪基]乙氧基]-乙醇,二盐酸盐;ETHANOL, 2-[2-[4-(5-OXIDODIBENZO[B,F][1,4]THIAZEPIN-11-YL)-1-PIPERAZINYL]ETHOXY]- ,DIHYDROCHLORIDE;喹硫平EP杂质S二盐酸盐(奎硫平亚砜二盐酸盐);喹硫平亚砜二盐酸盐;喹硫平杂质S (EP);喹硫平EP杂质S盐;化合物 T12619L;喹硫平亚砜双盐酸盐
英文名称	Quetiapine sulfoxide dihydrochloride
英文别名	ethanol, 2-[2-[4-(5-oxidodibenzo[b,f][1,4]thiazepin-11-yl)-1-piperazinyl]ethoxy]- ,dihydrochloride;2-[2-[4-(11-oxobenzo[b][1,4]benzothiazepin-6-yl)piperazin-1-yl]ethoxy]ethanol,dihydrochloride;Quetiapine sulfoxide (dihydrochloride);Quetiapine S-oxide dihydrochloride;Quetiapine sulfoxide dihydrochloride;Quetiapine EP Impurity S DiHCl (Quetiapine Sulfoxide DiHCl);Quetiapine EP Impurity S HCl Salt;QUETIAPINE SULFOXIDE DIHYDROCHLORIDE; QUETIAPINE S-OXIDE DIHYDROCHLORIDE
Cas No.	329218-11-3
分子式	C₂₁H₂₇Cl₂N₃O₃S
分子量	472.43
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	Quetiapine sulfoxide dihydrochloride (Quetiapine S-oxide dihydrochloride) 是 Quetiapinem 的主要代谢产物。Quetiapinem 是第二代抗精神病药。Quetiapine 是一种 5-HT 受体激动剂，也是一种多巴胺受体 (dopamine receptor) 拮抗剂。
生物活性	Quetiapine sulfoxide dihydrochloride (Quetiapine S-oxide dihydrochloride) is a main metabolite of Quetiapinem. Quetiapine is a second-generation antipsychotic. Quetiapine is a 5-HT receptors agonist and a dopamine receptor antagonist.
性状	Solid
体内研究(In Vivo)	The C max value (mean±SD) is estimated for Quetiapine sulfoxide (77.3±32.4 ng/mL). The AUC last value is estimated for Quetiapine sulfoxide (1,286±458 ng?h/mL). For Quetiapine sulfoxide, metabolic ratio decreases with time, from 119% on average 2 hours after dosing to 30% on average 72 hours after dosing. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Remmerie B, et al. Comparison of Capillary and Venous Drug Concentrations After Administration of a Single Dose of Risperidone, Paliperidone, Quetiapine, Olanzapine, or Aripiprazole. Clin Pharmacol Drug Dev. 2016 Nov;5(6):528-537. [2]. Cross AJ, et al. Quetiapine and its metabolite norquetiapine: translation from in vitro pharmacology to in vivo efficacy in rodent models. Br J Pharmacol. 2016 Jan;173(1):155-66.

溶解度数据	In Vitro: H₂O : 250 mg/mL (529.18 mM; Need ultrasonic)配制储备液

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