N-Desmethyl imatinib (Synonyms: N-去甲基伊马替尼; Norimatinib; Imatinib metabolite N-Desmethyl imatinib)
目录号: PL05628 纯度: ≥98%
CAS No. :404844-02-6
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中文名称
N-Desmethyl imatinib
中文别名
N-去甲基伊马替尼;N-脱甲基伊马替尼;甲砜霉素;甲磺酸伊马替尼杂质1;去甲磺酸伊马替尼;伊马替尼杂质B;伊马替尼杂质F
英文名称
N-Desmethyl imatinib
英文别名
Benzamide,N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-4-(1-piperazinylmethyl)-;Imatinib desmethyl (as formate);Imatinib metabolite N-Desmethyl Imatinib;N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(piperazin-1-ylmethyl)-benzamide;N-DESMETHYL GLEEVEC;N-Desmethyl Imatinib;Benzamide, N-(4-methyl-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)phenyl)-4-(1-piperazinylmethyl)-;CGP-74588;Imatinib metabolite;N Desmethyl imatinib;Norimatinib;N-{4-Methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}-4-(piperazin-1-ylmethyl)benzamide;N-Desmethylimatinib;6GOH0N63QD;n-desmethyl imatinib;n-{4-methyl-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)phenyl}-4-(piperazin-1-ylmethyl)benzamide;N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)-4-[(piperazin-1-yl)methyl]benzamide;Desmethyl Imatinib (Desmethyl Gleevec);CGP 74588;Imatinib EP Impurity C;n-Demethylated pi
Cas No.
404844-02-6
分子式
C28H29N7O
分子量
479.58
包装储存
Powder -20°C 3 years;4°C 2 years
产品详情
N-Desmethyl imatinib (Norimatinib) 是 Imatinib (HY-15463) 的代谢物。Imatinib 是一个靶向 v-Abl、c-Kit 和 PDGFR 多靶点抑制剂。
生物活性
N-Desmethyl imatinib (Norimatinib) is a metabolite of Imatinib (HY-15463). Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR.
性状
Solid
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years;4°C 2 years
参考文献
[1]. Robert A Parise, et al. Liquid chromatographic-mass spectrometric assay for quantitation of imatinib and its main metabolite (CGP 74588) in plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Jul 5;791(1-2):39-44.
溶解度数据
In Vitro: DMSO : 100 mg/mL (208.52 mM; Need ultrasonic)配制储备液
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1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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