Methylene blue hydrate|122965-43-9|(亚甲蓝水合物; Basic Blue 9 hydrate; CI-52015 hydrate; Methylthioninium chloride hydrate)-陌孚医药/Medlife

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Methylene blue hydrate (Synonyms: 亚甲蓝水合物; Basic Blue 9 hydrate; CI-52015 hydrate; Methylthioninium chloride hydrate)

目录号: PL05608

CAS No. :122965-43-9

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中文名称	Methylene blue hydrate
中文别名	次甲基兰水合物;亚甲基兰;亚甲基蓝水合物;亚甲基兰, 高纯,生物着色剂;亚甲基蓝;亚甲基蓝,AR;亚甲基蓝,IND;亚甲基蓝水合物, 高纯生物染色剂;亚甲兰;亚甲蓝 USP标准品;亚甲蓝水合物;次甲基蓝;甲基兰水合物;三水合亚甲基蓝;水合亚甲基蓝;3,7-双(二甲基氨基)吩噻嗪-5-鎓氯化物;碱性蓝9 水合物;亚甲基兰水合物;亚甲基兰, PRACT.;次甲基蓝水合物、次甲基兰水合物;亚甲蓝水合物;水合亚甲基蓝/次甲基蓝
英文名称	Methylene blue hydrate
英文别名	Methylene Blue hydrate;Basic Blue 9 hydrate;C.I. 52015 hydrate;Methylene Blue;Basic Blue 9~C.I. 52015;Methylene Blue hydrate,high purity biological stain;Methylene Blue hydrate,Methylthionini chloridum;Methylene Blue, high purity, biological stain;Methylene Blue,high purity;MethyleneblueHydrat;Methylthioninium chloride;Basic Blue 9;Methylthionini chloridum;3,7-Bis(dimethylamino)-5-phenothiazinium Chloride Hydrate;3,7-Bis(dimethylamino)phenothiazin-5-ium chloride;CI 52015;CINO 52015;METHYLENE BLUE EXTRA PURE;METHYLENE BLUE HYDRATE, PURE;METHYLENE BLUE FOR MICROSCOPY;Methylene Blue, high purity;O3YJW1TB3C;Phenothiazin-5-ium, 3,7-bis(dimethylamino)-, chloride, hydrate;3,7-Bis(dimethylamino)phenothiazin-5-ium chloride hydrate(1:1:x);Methylene Blue hydrate, 96+%, high purity biological stain;Methylene blue (TN);Methylene Blue xhydrate;Basic Blue 9 monohydrate;Methylene Blue monohydrate;C16H18N3S.Cl.H2O;C.i. basic Blue 9 monohydrate;HMS2093J19;6338AF
Cas No.	122965-43-9
分子式	C₁₆H₂₀ClN₃Os
分子量	337.87
包装储存	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

产品详情

Methylene blue (Basic Blue 9) hydrate 是一种鸟苷酸环化酶 (sGC)，单胺氧化酶 A (MAO-A) 和 NO 合酶 (NOS) 抑制剂。Methylene blue hydrate 是一种血管加压剂，在医疗中通常用作染料。Methylene blue hydrate 通过一氧化氮合成酶/鸟苷酸环化酶信号通路降低脉冲前抑制。Methylene blue hydrate 是一种氧化还原循环化合物，能够穿过血脑屏障。Methylene blue hydrate 是Tau 聚集抑制剂。亚甲蓝可减轻脑水肿，减弱小胶质细胞活化，减少神经炎症。

生物活性

Methylene blue (Basic Blue 9) hydrate is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue is a vasopressor and is often used as a dye in several medical procedures. Methylene blue hydrate through the nitric oxide syntase/guanylate cyclase signalling pathway to reduce prepulse inhibition. Methylene blue hydrate is a REDOX cycling compound and able to cross the blood-brain barrier. Methylene blue hydrate is a Tau aggregation inhibitor. Methylene blue hydrate reduces cerebral edema, attenuated microglial activation and reduced neuroinflammation.

性状

Solid

体外研究(In Vitro)

Methylene blue (Basic Blue 9) hydrate (4.5 μM; BV2 microglia) alters the immune profile of LPS-activated BV2 microglia and decreased the level of CD14, IL-1β, TNF-α, and CCL2 mRNA. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Methylene blue (Basic Blue 9) hydrate (50 and 100 mg/kg; i.p.; once, for 25 min; male NMRI mice) reduces absent prepulse inhibition.
Methylene blue hydrate (20 and 40 mg/kg; p.o.; daily, for 6 months; CaMKIIα-tTA transactivator mice) preserves cognition in mice expressing full-length pro-aggregant human Tau.
Methylene blue hydrate (2 mg/kg; i.v.; once, for 1 d; TBI-treated male BALB/c mice) reduces TBI-induced edema and neuroinflammation and reduces acute depression-like behavior.
Methylene blue hydrate (2 mg/kg; i.v.; once, for 1 d; TBI-treated male BALB/c mice) reduces the percentage of inflammatory factor. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

ClinicalTrial

参考文献

[1]. Klamer D, et, al. Phencyclidine-induced behaviour in mice prevented by methylene blue. Basic Clin Pharmacol Toxicol. 2004 Feb;94(2):65-72.
[2]. Hochgr?fe K, et, al. Preventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau. Acta Neuropathol Commun. 2015 May 10;3:25.

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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