Corticosterone-d8 (Synonyms: 皮质酮 d
目录号: PL05538
CAS No. :1271728-07-4
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中文名称
Corticosterone-d8
中文别名
4-庚酮;皮质酮-D8
英文名称
Corticosterone-d8
英文别名
Corticosterone-d8 (Major);Corticosterone-d8;(8S,9S,10R,11S,13S,14S,17S)-2,2,4,6,6,17-hexadeuterio-17-(2,2-dideuterio-2-hydroxyacetyl)-11-hydroxy-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-3-one
Cas No.
1271728-07-4
分子式
C21H30O4
分子量
346.46
包装储存
Please store the product under the recommended conditions in the Certificate of Analysis.
产品详情
Corticosterone-d8 是 Corticosterone 的氘代物。Corticosterone是一种肾上腺皮质类固醇,作为盐皮质激素和糖皮质激素具有适度但显着的活性。
生物活性
Corticosterone-d 8 is the deuterium labeled Corticosterone. Corticosterone is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.
体外研究(In Vitro)
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
[2]. Gasser PJ, et al. Corticosterone-sensitive monoamine transport in the rat dorsomedial hypothalamus: potential role for organiccation transporter 3 in stress-induced modulation of monoaminergic neurotransmission. J Neurosci. 2006 Aug 23;26(34):8758-8766.
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