Tolmetin|26171-23-3|(托麦汀)-陌孚医药/Medlife

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Tolmetin (Synonyms: 托麦汀)

目录号: PL05553 纯度: ≥98%

CAS No. :26171-23-3

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中文名称	Tolmetin
中文别名	托麦汀;2-[1-甲基-5-(4-甲基苯甲酰)吡咯-2-基]乙酸;托美汀
英文名称	Tolmetin
英文别名	1-Methyl-5-p-toluoylpyrrole-2-acetic acid;2-[1-Methyl-5-(4-methylbenzoyl)-pyrrol-2-yl]acetic acid;2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetic acid;TOLMETIN;[3H]-Tolmetin;1-methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetic acid;1-methyl-5-(4-methylbenzoyl)pyrrol-2-acetic acid;2-(1-Methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl)acetic acid;5-(4-methylbenzoyl)-1-methyl-pyrrol-2-ylace;5-(p-toluoyl)-1-methylpyrrole-2-acetic acid;Tolectin;Tolmetina;Tolmetina [DCIT];Tolmetine [INN-French];Tolmetino;Tolmetinum;Tolmetine;Tolmetinum [INN-Latin];Tolmetino [INN-Spanish];1H-Pyrrole-2-acetic acid, 1-methyl-5-(4-methylbenzoyl)-;MCN 2559;1-Methyl-5-(4-methylbenzoyl)-pyrrole-2-acetic acid;Acido 1-metil-5-(p-tolnil)-pirrol-2-acetico;EIN
Cas No.	26171-23-3
分子式	C₁₅H₁₅NO₃
分子量	257.28
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	Tolmetin 是一种具有口服活性的，有效的 COX 抑制剂，对人 COX-1 和 COX-2 的 IC₅₀ 值分别为 0.35 µM 和 0.82 µM。Tolmetin 属于非甾体类物质，具有强效的抗炎活性。
生物活性	Tolmetin is an orally active and potent COX inhibitor with IC 50 s of 0.35 μM and 0.82 μM human COX-1 and COX-2, respectively. Tolmetin is a non-steroidal anti-inflammatory drug (NSAID).
性状	Solid
IC50 & Target[1][2]	Human COX-1 0.35 μM (IC50) Human COX-2 0.8
体外研究(In Vitro)	Tolmetin (0.25 mM) does not attenuate lipid peroxidation in rat brain homogenate. Tolmetin (0.25, 0.5, 0.75, 1 mM) shows radical scavenging properties but without superoxide anion generation in rat brain homogenat. Tolmetin (0.001-100 μM) shows anticancer activity againts HT-29 colon cancer cell line in a dose-dependent manner. Tolmetin (0-100 μM) shows no effect on osteoblast growth. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Tolmetin (30,100 mg/kg; gavage; single dose or twice daily for 3 and 14 days) shows maximal ulcerogenic effect 4 h after the single dose, while potently decreases after 3 and 14 days of repeated administration in male Wistar rats weighing 180-200 g. Tolmetin causes gastric lesions in 100 mg/kg. Tolmetin (5 mg/kg twice a day for 5 days) pre-treatment considerably attenuates quinolinic acid (QA)-induced neurotoxicity. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. T D Warner, et al. Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis. Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7563-8. [2]. DADA?, Yakup, et al. Synthesis and anticancer activity of some novel tolmetin thiosemicarbazides. Marmara Pharmaceutical Journal 19(3) ? April 2015

溶解度数据	In Vitro: DMSO : 100 mg/mL (388.68 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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