Dexamethasone phosphate disodium|2392-39-4|(地塞米松磷酸钠; Dexamethasone 21-phosphate disodium)-陌孚医药/Medlife

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Dexamethasone phosphate disodium (Synonyms: 地塞米松磷酸钠; Dexamethasone 21-phosphate disodium)

目录号: PL05555 纯度: ≥99%

CAS No. :2392-39-4

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中文名称	Dexamethasone phosphate disodium
中文别名	地塞米松磷酸钠;16alpha-甲基-11beta,17alpha,21-三羟基-9alpha-氟孕甾-1,4-二烯-3,20-二酮-21-磷酸酯二钠盐;21-磷酸地塞米松二钠盐;21-磷酸地塞米松;地塞米松磷酸钠原粉;地塞米松21-磷酸二钠盐水合物;Dexamethasone 21-Phosphate Disodium Salt Hydrate 地塞米松21-磷酸二钠盐水合物;地塞美松磷酸钠;地塞米松;地塞米松磷酸钠标准品;地塞米松磷酸钠皮质激素;地塞米松磷酸钠,Dexamethasone 21-phosphate disodium salt;磷酸地塞米松钠;16Α-甲基-11Β,17Α,21-三羟基-9Α-氟孕甾-1,4-二烯-3,20-二酮-21-磷酸酯二钠盐;地塞米松磷酸钠,16alpha-甲基-11beta,17alpha,21-三羟基-9alpha-氟孕甾-1,4-二烯-3,20-二酮-21-磷酸酯二钠盐;癸胺;地塞米松磷酸二钠
英文名称	Dexamethasone phosphate disodium
英文别名	dexamethasone 21-phosphate disodium salt;Dexamethasone Phosphate Sodium;dexamethasone 21-(disodium phosphate);DEXAMETHASONE SODIM PHOSPHATE;Dexamethasone Sodium Phosphate;Dexamethasone 21-Phosphate Disodium Salt Hydrate;DecylaMine;Pregna-1,4-diene-3,20-dione,9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, disodium salt, (11b,16a)- (9CI);Pregna-1,4-diene-3,20-dione, 9-fluoro-11b,17,21-trihydroxy-16a-methyl-,21-(dihydrogen phosphate) disodium salt (8CI);Pregna-1,4-diene-3,20-dione,9-fluoro-11b,17,21-trihydroxy-16a-methyl-, 21-phosphate disodium salt (6CI);Ak-Dex;Baldex;Colvasone;Corson;Corson (pharmaceutical);Dalalone;Decadronphosphate;Decdan;Dexabene;Dexacort;Dexadreson;Dexagel;Dexagro;Dexamethasone disodium phosphate;Dexamethasone phosphate disodium salt;Dexamethasone phosphate sodium salt;Dexamethazone sodium phosphate;Dezone;Disodium dexamethasone 21-monophosphate;Disodium dexamethasone 21-phosphate;Disodium dexamethasone phosphate;MaxidexOintment;Megacort;Onadron;Orgadrone;Sodium dexamethasone phosphate;Soldesam;Solu-Deca;Solu-Decadron;Spersadex;Turbinaire;9-Fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)pregna-1,4-diene-3,20-dione disodium salt;地塞米松磷酸钠;Dexamethasone 21-phosphate disodiumsalt;Spersadox;Maxidex Ointment;Decadron phosphate;Hexadrol Injectable;Dexamethasone phosphate disodium;21-Disodium phosphate dexamethasone;Dexamethasone Sodium;Dexamethasone 21-phosphate disodium salt;Dexamethasone 21-(disodium phosphate);Dexamethasone sodium phosphate
Cas No.	2392-39-4
分子式	C₂₂H₂₈FNa₂O₈P
分子量	516.40
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情

Dexamethasone phosphate disodium 是一种具有口服活性的糖皮质激素受体激动剂。

生物活性

Dexamethasone phosphate disodium 是一种具有口服活性的糖皮质激素受体激动剂。

性状

Solid

IC50 & Target[1][2]

Glucocorticoid receptor

体外研究(In Vitro)

Dexamethasone regulates several transcription factors, including activator protein-1, nuclear factor-AT, and nuclear factor-kB, leading to the activation and repression of key genes involved in the inflammatory response. Dexamethasone potently inhibits granulocyte-macrophage colony stimulating factor (GM-CSF) release from A549 cells with EC50 of 2.2 nM. Dexamethasone (EC50=36 nM) induces transcription of the β2-receptor is found to correlate with glucocorticoid receptor (GR) DNA binding and occurred at 10-100 fold higher concentrations than the inhibition of GM-CSF release. Dexamethasone (IC50=0.5 nM) inhibits a 3×κB (NF-κB, IκBα, and I-κBβ), which is associated with inhibition of GM-CSF release. has not independently confirmed the accuracy of these methods. They are for refer

体内研究(In Vivo)

Treatment with Dexamethasone at a dose of 2×5 mg/kg efficiently inhibits lipopolysaccharide (LPS)-induced inflammation. In our experimental system, treatment with a single dose of Dexamethasone 10 mg/kg (i.p.) significantly decreases recruitment of granulocytes as well as spontaneous production of oxygen radicals compared with animals expose to LPS and injected with solvent alone (saline). The effects are statistically significant when administered both 1 h before and 1 h after inhalation of LPS. The number of granulocytes in BALF decreased to levels comparable to healthy animals (given an aerosol of water). Rats treated with Dexamethasone consume less food and weighed less than control rats. Treated rats also weigh less than pair-fed animals though their food intake is similar. Five days of Dexamethasone injection result in a significant increase in both the liver mass (+42%)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. LaLone CA, et al. Effects of a glucocorticoid receptor agonist, Dexamethasone, on fathead minnow reproduction, growth, and development. Environ Toxicol Chem. 2012 Mar;31(3):611-22.
[2]. Adcock IM, et al. Ligand-induced differentiation of glucocorticoid receptor (GR) trans-repression and transactivation: preferential targetting of NF-kappaB and lack of I-kappaB involvement. Br J Pharmacol. 1999 Jun;127(4):1003-11.

溶解度数据	In Vitro: H₂O : ≥ 100 mg/mL (193.65 mM)DMSO : 1 mg/mL (1.94 mM; ultrasonic and warming and heat to 80°C)

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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