Beclometasone|4419-39-0|(倍氯米松; Beclomethasone)-陌孚医药/Medlife

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Beclometasone (Synonyms: 倍氯米松; Beclomethasone)

目录号: PL05530 纯度: ≥98%

CAS No. :4419-39-0

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中文名称	Beclometasone
中文别名	倍氯美松;倍氯米松;甲醇中倍氯米松溶液标准物质;倍氯米松标准品;倍氯米松杂质;9α-氯-11β,17α,21-三羟基-16β-甲基孕甾-1,4-二烯-3,20-二酮;9α-氯-16β-甲基孕甾-1,4-二烯-11β,17α,21-三醇-3,20-二酮;倍氯松倍氯美松
英文名称	Beclometasone
英文别名	Pregna-1,4-diene-3,20-dione,9-chloro-11,17,21-trihydroxy-16-methyl-, (11b,16b)-;Beclomethasone;Beclomethasone Solution;(8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one;9-Chloro-11beta,17,21-trihydroxy-16beta-methyl-pregna-1,4-diene-3,20-dione;9-Chloro-16beta-methylprednisolone;9alpha-Chloro-16beta-methylprednisolone;Beclometasone;Becolvent
Cas No.	4419-39-0
分子式	C₂₂H₂₉O₅Cl
分子量	408.92
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情

Beclometasone (Beclomethasone) 是一种糖皮质激素受体 (glucocorticoid receptor) 激动剂。

生物活性

Beclometasone (Beclomethasone) is a prototype glucocorticoid receptor agonist.

性状

Solid

IC50 & Target[1][2]

Glucocorticoid Receptor

体外研究(In Vitro)

An inhibition of the normal physiological neutrophil migration and of neutrophil chemotaxis directed by wounding-induced inflammation is detected at 4 h after administration of 25 μM Beclomethasone. Tumour cell invasion and micrometastasis is also reduced in embryos incubated in 25 μM Beclomethasone 4 h before implantation. In addition, the lysyl oxidase inhibitor β-aminoproprionitrile (βAPN) largely reduces fibrillar collagen and enhances the CHT-TF transmigration of neutrophils, leading to a significant increase of tumour cell invasion and subsequent formation of micrometastases. Notably, βAPN inhibits neutrophil chemotaxis induced by inflammation, indicating that the increase of tumour cell invasion in βAPN-treated embryos is correlated with enhanced non-pathological neutrophil migration, but not with inflammation. h

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；4°C 2 years

ClinicalTrial

参考文献

[1]. He S, et al. Neutrophil-mediated experimental metastasis is enhanced by VEGFR inhibition in a zebrafish xenograft model. J Pathol. 2012 Aug;227(4):431-45.

溶解度数据	In Vitro: DMSO : ≥ 32 mg/mL (78.25 mM)配制储备液

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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