Benactyzine hydrochloride|57-37-4|(胃复康)-陌孚医药/Medlife

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Benactyzine hydrochloride (Synonyms: 胃复康)

目录号: PL05532 纯度: ≥99%

CAS No. :57-37-4

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中文名称	Benactyzine hydrochloride
中文别名	盐酸贝那替嗪;盐酸苯乃嗪;乙胺痉平;2-二乙基氨基乙基 2-羟基-2,2-二苯乙酸酯盐酸盐;Benactyzine Hydrochloride 盐酸贝那替嗪;盐酸贝那替秦;2-(二乙基氨基)乙基二苯乙醇酸酯盐酸盐;苯羟乙胺盐酸盐;二苯乙醇酸-2-(二乙氨基)乙酯盐酸盐;盐酸苯那辛;胃复康
英文名称	Benactyzine hydrochloride
英文别名	benactyzine hydrochloride;Benactyzine HCL;2-Diethylaminoethyl Diphenylglycolate Hydrochloride;2-(diethylamino)ethyl 2-hydroxy-2,2-diphenylacetate,hydrochloride;BENACTYINE HYDROCHLORIDE;Benzilic Acid 2-(Diethylamino)ethyl Ester Hydrochloride;2-(Diethylamino)ethyl Benzilate Hydrochloride;2-Diethylaminoethyl 2-hydroxy-2,2-diphenylacetate hydrochloride;Neuroleptone;Tranquilline;Amitakon;Valladon;Ibiotyzil;Destendo;Benaktin;Valladan;Neurobenzil;Neuraktil;Nervatil;Nervacton;Leucidil;Suavitil;Prokalm;Procalm;Amysyl;Stoikon;Parpon;Katron;Cevanol;Phobex;Nutinal;Amyzyl;Amizil;Aktozin;Parazan;Parasan;Lucidil;Cafron;Arkadin;Amisyl;Amisil;Fobex;Cedad;Amizil hydrochloride;Benactyzine chloride;Amizyl hydrochloride;Morcain;Benactizine hydrochloride;Benactyzin [Czech];2-(diethylamino)ethyl 2-hydroxy-2,2-diphenylacetate hyd;57-37-4;NC00319;EA 2092;Opera_ID_144;s3701;SCHEMBL4419579;2-(Difenyl-hydroxyacetoxy)ethyl-diethylammoniumchlorid;WLN: QXR&R&VO2N2&2 &GH;Ethanol, 2-(diethylamino)-, benzilate hydrochloride;D88595;beta-Diethylaminoethyl benzilate hydrochloride;Benactyzine HCl;BENACTYZINE HYDROCHLORIDE [VANDF];2-(diethylamino)ethyl 2-hydroxy-2,2-diphenylacetate hydrochloride;Benzilic acid, 2-(diethylamino)ethyl ester hydrochloride;SMR000059142;MFCD00012624;MLS000069801;CHEMBL1584883;Diphenylglycollic acid 2-(diethylamino)ethyl ester hydrochloride;DS-11395;HY-B1542A;Ethanol, benzilate hydrochloride;NSC-16339;BENACTYZINE HYDROCHLORIDE [WHO-DD];B0053;2-(diethylamino)ethyl 2-hydroxy-2,2-diphenylacetate;hydrochloride;Benactyzine hydrochloride, >=98% (HPLC);Benactyzine hydrochloride;NSC 16339;CS-8073;.beta.-Diethylaminoethyl benzilate hydrochloride;Benactizine;MLS001148661;AKOS015901413;2-diethylaminoethyl 2-hydroxy-2,2-diphenylacetate hydrochloride;AY-5406-1;Benzeneacetic acid, .alpha.-hydroxy-.alpha.-phenyl-, 2-(diethylamino)ethyl ester, hydrochloride (1:1);Benzilic acid, 2-(diethylamino)ethyl ester, hydrochloride;CCG-101069;AI3-26379;Amioyl;UNII-26R628272Q;Q27254124;2-Diethylaminoethylester kyseliny benzilove hydrochlorid;DTXSID8052774;2-(Difenyl-hydroxyacetoxy)ethyl-diethylammoniumchlorid [Czech];2-(Diethylamino)ethyl benzilate hydrochloride;Benzilic acid beta-diethylaminoethyl ester hydrochloride;57-37-4 (HCl);FT-0612170;AY 5406-1;EINECS 200-324-4;26R628272Q;BENACTYZINE HYDROCHLORIDE [MI];2-Diethylaminoethyl benzilate hydrochloride;AC-32563;AY-5406;LS-32471;Benzilate du diethylamino-ethanol chlorhydrate;Benzeneacetic acid, alpha-hydroxy-alpha-phenyl-, 2-(diethylamino)ethyl ester, hydrochloride;2-Diethylaminoethyl diphenylglycolate hydrochloride;Benzilic acid .beta.-diethylaminoethyl ester hydrochloride;Tranquillin;2-Diethylaminoethylester kyseliny benzilove hydrochlorid [Czech];Benzeneacetic acid, alpha-hydroxy-alpha-phenyl-, 2-(diethylamino)ethyl ester, hydrochloride (1:1);Win 5606;Benzeneacetic acid, .alpha.-hydroxy-.alpha.-phenyl-, 2-(diethylam...
Cas No.	57-37-4
分子式	C₂₀H₂₆ClNO₃
分子量	363.88
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	Benactyzine hydrochloride 是一种丁酰胆碱酯酶 (BChE) 抑制剂，其 K_i 值为 0.010 mM。
生物活性	Benactyzine hydrochloride is a butyrylcholinesterase (BChE) inhibitor with a K i of 0.010 mM.
性状	Solid
IC50 & Target[1][2]	Ki: 0.010 mM (BChE)
体外研究(In Vitro)	Benactyzine hydrochloride and drofenine are widely used anticholinergic drugs which are also competitive inhibitors of BChE with Ki values of 0.010±0.001 and 0.003±0.000 mM, respectively. Results indicate that the inhibition of BChE by Benactyzine hydrochloride is pure or partial competitive. Pure competitive inhibition can be distinguished from partial competitive inhibition by plotting v vs [Benactyzine] at a fixed [BTCh]. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Benactyzine hydrochloride (1 mg/kg) does not influence the attention response. Benactyzine hydrochloride increases the duration of the exploratory-motor reaction, but slightly diminishes the salivation elicited by acetylcholine. There is no blocking effect of Benactyzine hydrochloride and promazine on the EEG-seizure activity elicited by acetylcholine, and almost no inhibitory effect on emotional reactions. Emotional reactions are blocked by high doses of imipramine and promazine, but not by Benactyzine hydrochloride. The data indicates that imipramine, promazine and Benactyzine hydrochloride influence the autonomic effects of serotonin in different ways. Promazine, and especially Benactyzine hydrochloride, inhibit and shorten the period of salivation elicited by the intra-amygdaloid injection of serotonin. has not ind
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Bodur E, et al. Inhibition effects of benactyzine and drofenine on human serum butyrylcholinesterase. Arch Biochem Biophys. 2001 Feb 1;386(1):25-9. [2]. Allikmets LH, et al. Dissimilar influences of imipramine, benactyzine and promazine on effects of micro-injections ofnoradrenaline, acetylcholine and serotonin into the amygdala in the cat. Psychopharmacologia. 1969;15(5):392-403.

溶解度数据	In Vitro: DMSO : 150 mg/mL (412.22 mM; Need ultrasonic and warming)H₂O : 50 mg/mL (137.41 mM; Need ultrasonic)配制储备液

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