Ethoxyquin|91-53-2|(乙氧基喹啉)-陌孚医药/Medlife

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Ethoxyquin (Synonyms: 乙氧基喹啉)

目录号: PL05517 纯度: ≥98%

CAS No. :91-53-2

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中文名称	Ethoxyquin
中文别名	乙氧基喹啉;6-乙氧基-2,2,4-三甲基-1,2-二氢化喹啉;防老剂AW;虎皮灵;山道喹;乙氧喹;防老化剂AN;乙氧喹啉;6-乙氧基-1,2-二氢-2,2,4-三甲基喹啉;促长啉;6-乙氧-1,2-二氫-2,2,4-三甲喹啉;抗氧宝;珊多喹;衣索金;6-乙氧基-2,2,4-三甲基-1,2-二氢喹啉[橡胶抗氧化剂];7,8-二甲基咯嗪;橡胶防老剂AW;乙氧基喹;乙氧基喹啉标准品;乙氧基喹啉（Ethoxyquin）;乙氧喹啉标准品;乙氧喹啉（乙氧基喹啉）;1,2-二氢-6-乙氧基-2,2,4-三甲基喹啉;6-乙氧基-2,2,4-三甲基-1,2-二氢喹啉;促长啉,Ethoxyquin ,分析标准品;山道喹,虎皮灵,乙氧喹,防老剂AW,6-乙氧基-2,2,4-三甲基-1,2-二氢喹啉,EQ或EMQ,乙氧基喹啉原油;乙氧基喹啉,Ethoxyquin,分析标准品;优质高纯，乙氧喹啉
英文名称	Ethoxyquin
英文别名	6-Ethoxy-2,2,4-trimethyl-1,2-dihydroquinoline;1,2-DIHYDRO-6-ETHOXY-2,2,4-TRIMETHYLQUINOLINE;6-ETHOXY-1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE;RALUQUIN (R);SANTOQUIN;SANTOQUIN(R);STOP-SCALD;1,2-dihydro-2,2,4-trimethyl-6-ethoxyquinoline;2,2,4-trimethyl-6-ethoxy-1,2-dihydroquinoline;6-ethoxy-1,2-dihydro-2,2,4-trimethyl-quinolin;6-Ethoxyl-2,2,4-trimethyl-1,2-dihydrquinoline;amea100;antageaw;AntioxidantAW;antioxidantec;ariesantox;dawe’snutrigard;emq;Ethoxyquin;6-Ethoxy-2,2,4-trimethyl-1,2-dihydroquinoline [Antioxidant for rubber];1,2-dihydro-2,2,4-trimethylquinolin-6-yl ethyl ether;ETMDQ;niflex;niflexd;nocracaw;quinoled;usafb-24;Ethoxyquine;Santoquine;Antioxidant EC;Santoflex A;Santoflex AW;Nix-Scald;Dawe's nutrigard;Nocrack AW;Quinol ED;Permanax 103;Aries Antox;Niflex D;Nocrac AW;Antage AW;Alterungsschutzmittel EC;Ethoxychin;(-)-Normetazocine;Quinoline, 6-ethoxy-1,2-dihydro-2,2,4-trimethyl-;Amea 100;Santoquine (VAN);Ethoxyquin [ISO];6-Ethoxy-1,2-dihydro-2,2,4-trimethylquin;6-Ethoxy-1,2-dihydro-2,2,4-trimethylquinoline (ACI);1,2-Dihydro-2,2,4-trimethyl-6-ethoxyquinoline;1,2-Dihydro-6-ethoxy-2,2,4-trimethylquinoline;2,2,4-Trimethyl-1,2-dihydro-6-ethoxyquinoline;2,2,4-Trimethyl-6-ethoxy-1,2-dihydroquinoline;Antioxidant AW;Antox;AW;Biox SE;BIOX-S;EMQ;EQ;MeSH ID: D005015;Niflex;Nocrac AW-G;Nonflex AW;Nonflex AW-P;NSC 6795;Raluquin;Rendox EQ;Santoquin;Stop-Scald;Tenox II;6-Ethoxy-1,2-dihydro-2,2,4-trimethylquinoline
Cas No.	91-53-2
分子式	C₁₄H₁₉NO
分子量	217.31
包装储存	Pure form -20°C 3 years；4°C 2 years

产品详情	Ethoxyquin 是一种多年来用于动物饲料的抗氧化剂，也是热休克蛋白 90 (Hsp90) 的抑制剂。
生物活性	Ethoxyquin is an antioxidant which has been used in animal feed for many years and also an inhibitor of heat shock protein 90 (Hsp90).
性状	Liquid
IC50 & Target[1][2]	HSP90
体外研究(In Vitro)	Ethoxyquin (EQ) does not block Paclitaxel’s (PTX’s) ability to induce cell death in 4 different breast cancer cell lines. Results demonstrate that only when Hsp90 level is down regulated is neuroprotec-tion provided by Ethoxyquin (EQ) no longer seen. It is found that Ethoxyquin provides neuroprotection with a best efficacy range from 30 to 300?nM. It is interesting to note that higher (μM) concentrations of Ethoxyquin do not provide further neuroprotection and in fact at these higher concentrations Ethoxyquin loses its neuroprotective effects. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Ethoxyquin (EQ) provides a dose-dependent neuroprotection. Although all 3 doses of Ethoxyquin provide partial neuroprotection against reduction in intraepidermal nerve fiber density, the peak efficacy is with the 75 μg/kg dose. Rats treated with Ethoxyquin (EQ) alone or control vehicle treated rats gain weight as expected under normal physiological conditions. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Pure form -20°C 3 years；4°C 2 years
参考文献	[1]. Sadikot T, et al. Development of a high-throughput screening cancer cell-based luciferase refolding assay for identifying Hsp90 inhibitors. Assay Drug Dev Technol. 2013 Oct;11(8):478-88. [2]. Zhu J, et al. Ethoxyquin prevents chemotherapy-induced neurotoxicity via Hsp90 modulation. Ann Neurol. 2013 Dec;74(6):893-904.

溶解度数据	In Vitro: DMSO : ≥ 50 mg/mL (230.09 mM)H₂O : < 0.1 mg/mL (insoluble)

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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