Clofibric acid-d4|1184991-14-7|(Chlorofibrinic acid-d-陌孚医药/Medlife

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Clofibric acid-d4 (Synonyms: Chlorofibrinic acid-d

目录号: PL05513

CAS No. :1184991-14-7

商品编号	规格	价格	会员价
PL05513-1mg	1mg	询价	询价
PL05513-5mg	5mg	询价	询价
PL05513-10mg	10mg	询价	询价

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中文名称	Clofibric acid-d4
中文别名	3-(2-溴乙酰基)-5-氯-N-(3-甲氧基丙基)-2-噻吩磺酰胺;4-氯苯氧异丁酸-D4氘代;降固醇酸-d4(4-氯苯基-d4)
英文名称	Clofibric acid-d4
英文别名	Clofibric-d4 acid;2-(4-chloro-2,3,5,6-tetradeuteriophenoxy)-2-methylpropanoic acid;Chlorophibrinic-d4 Acid
Cas No.	1184991-14-7
分子式	C₁₀H₁₁O₃Cl
分子量	214.65
包装储存	Please store the product under the recommended conditions in the Certificate of Analysis.

产品详情	Clofibric acid-d₄ 是 Clofibric acid 的氘代物。Clofibric acid (Chlorofibrinic acid)，一种脂质纤维调节剂 Clofibrate，Etofibrate 和 Etofyllinclofibrate 活性代谢物，是 PPARα 的激动剂，具有降血脂作用。Clofibric acid 也是一种除草剂。
生物活性	Clofibric acid-d 4 is the deuterium labeled Clofibric acid. Clofibric acid (Chlorofibrinic acid), the pharmaceutically active metabolite of lipid regulators Clofibrate, Etofibrate and Etofyllinclofibrate, is a PPARα agonist which exhibits hypolipidemic effects. Clofibric acid also is an herbicide[1][2][3].
体外研究(In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Forman BM, et, al. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta. Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4312-7.

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