Methylene blue trihydrate|7220-79-3|(亚甲蓝三水合物; C.I. Basic Blue 9 trihydrate)-陌孚医药/Medlife

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Methylene blue trihydrate (Synonyms: 亚甲蓝三水合物; C.I. Basic Blue 9 trihydrate)

目录号: PL05504 纯度: ≥98%

CAS No. :7220-79-3

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中文名称	Methylene blue trihydrate
中文别名	亚甲基蓝;次甲基蓝;三水合亚甲基蓝;3,7-双(二甲氨基)吩噻嗪-5-翁氯化物;次甲基兰;碱性湖蓝BB;碱性亚甲天蓝;品蓝;三水;WAKO135-17571碱性亚甲蓝三水合物标准品;次甲基兰DNA染色液;次甲基蓝批量;次甲基蓝亚甲基蓝;次甲基蓝(亚甲基蓝);次甲基蓝,Amresco;次甲基蓝,IND;次甲基蓝DNA染色液;磺胺甲噁唑钠;碱性亚甲蓝三水合物;亚甲基兰;亚甲基蓝次甲基蓝;亚甲基蓝三水合物;亚甲基蓝（三水）;亚甲基蓝,AR;亚甲基蓝,BS;亚甲基蓝溶液;亚甲基蓝三水合物, 用于生物染色;亚甲基蓝三水合物标准品;亚甲兰;亚甲蓝;亚甲蓝(三水);亚甲蓝三水合物标准品;次甲基兰DNA染色液,Methylene blue,100X DNA STAIN;次甲基蓝,三水;甲基蓝,亚甲蓝,品蓝,美蓝,四甲基蓝,盐基湖蓝,碱性亚甲蓝,亚甲基天蓝,碱性蓝9,三水合亚甲基蓝,氯化四甲基硫堇,碱性湖蓝,亚甲基兰;氯化-3,7-双(二甲胺基)吩噻咛-5-鎓;四甲基蓝;亚甲基蓝指示剂级;亚甲基蓝,Methylene blue,BS;亚甲基蓝,Methylene blue,IND;亚甲基蓝,三水;亚甲基天蓝;亚甲蓝,品蓝,亚甲基兰,碱性蓝9,四甲基蓝,次甲基蓝,次甲基兰,亚甲兰,碱性湖蓝BB,碱性亚甲天蓝,盐基湖蓝,盐基湖蓝BB,亚甲基天蓝,3,7-双(二甲氨基)吩噻嗪-5-翁氯化物,次甲基蓝,三水;盐基湖蓝BB;用于生物学染色;亚甲基蓝 ;亚甲蓝三水合物;亚甲基蓝水合物
英文名称	Methylene blue trihydrate
英文别名	Methylene Blue trihydrate;Basic Blue 9~C.I. 52015;C.I. 52015;methylene blue solution;MethyleneBluepract;Methylene Blue;Basic Blue 9;Basic Blue 9 trihydrate;C.I. 52015 trihydrate;Methylene Blue trihydratee;3,7-bis(Dimethylamino)phenazathionium chloride;METHYLENE BLUE CHLORIDE TRIHYDATE;BASIC BLUE 9 HYDRATE;Indicator;Methylene Blue BB;METHYLENE BLUE HYDRATE;Methylene Blue trihy;Methylene blue trihydrate [for biological staining];METHYLENE BLUE TS;3,7-Bis(dimethylamino)phenothiazin-5-ium chloride;Methylthionine chloride;C.I. Basic Blue 9 trihydrate;Phenothiazin-5-ium, 3,7-bis(dimethylamino)-, chloride, trihydrate;3,7-Bis(dimethylamino)phenothiazin-5-ium chloride trihydrate;T42P99266K;Methylene blue (USP);Methylene blue [USP];Methylthionine HCl;Methylene Blue trihydrate (C.I. 52015);Methylene Blue, high purity, biological stain;Methylene Blue trihydrate, 95%, pure;Methylene Blu
Cas No.	7220-79-3
分子式	C₁₆H₂₄ClN₃O₃S
分子量	373.90
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情

Methylene blue trihydrate (C.I. Basic Blue 9 trihydrate) 是一种鸟苷酸环化酶 (sGC)，单胺氧化酶 A (MAO-A) 和 NO 合酶 (NOS) 抑制剂。Methylene blue trihydrate 是一种血管加压药，在医疗中通常用作染料。Methylene blue trihydrate 具有抗伤害感受，抗疟疾，抗抑郁和抗焦虑作用，可用于高铁血红蛋白血症，神经退行性疾病和异环磷酰胺引起的脑病的研究。

生物活性

Methylene blue trihydrate (C.I. Basic Blue 9 trihydrate) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue trihydrate is a vasopressor and is often used as a dye in several medical procedures. Methylene blue trihydrate has antinociception, antimalarial, antidepressant and anxiolytic activity effects. Methylene Blue trihydrate has the potential for methemoglobinemias, neurodegenerative disorders and ifosfamide-induced encephalopathytreatment.

性状

Solid

IC50 & Target[1][2]

Plasmodium

体外研究(In Vitro)

By acting as an alternative electron acceptor/donor Methylene blue restores mitochondrial function, improves neuronal energy production and inhibits the formation of superoxide.
Methylene blue inhibits cytochrome P450 (CYP) isozymes. Methylene blue is an odorless, water soluble, dark blue-green crystalline powder, which turns blue whenever mixed in solution. Methylene blue is a vasopressor that impacts the NO synthetic pathway by inhibiting inducible NOS and inhibiting the subsequent activation of sGC. In addition, by binding to the iron heme moiety of sGC and causing enzyme inhibition, Methylene blue blocks accumulation of cyclic GMP (cGMP), competing directly with NO in its ability to activate soluble guanylyl cyclase. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Methylene Blue (1, 5, and 25 μg/rat) significantly decreases sevoflurane minimum alveolar anesthetic concentration (MAC) and brain cyclic guanosine monophosphate (cGMP) content in a dose-dependent manner in male Sprague-Dawley rats (7-week-old, 200-250 g).
Methylene blue is used as a dye in chromoendoscopy, and is sprayed onto the mucosa of the gastrointestinal tract in order to identify dysplasia, or pre-cancerous lesions.
Methylene blue is able to restore vascular tone, normalize mean arterial pressures (MAP), and reduce vasopressor usage. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；4°C 2 years

ClinicalTrial

参考文献

[1]. Delport A, et al. Methylene blue and its analogues as antidepressant compounds. Metab Brain Dis. 2017 Oct;32(5):1357-1382.
[2]. Masaki E, et al. Methylene blue, a soluble guanylyl cyclase inhibitor, reduces the sevoflurane minimum alveolar anesthetic concentration and decreases the brain cyclic guanosine monophosphate content in rats. Anesth Analg. 1999 Aug;89(2):484-9.

溶解度数据	In Vitro: DMSO : 100 mg/mL (267.45 mM; Need ultrasonic)配制储备液

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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