N-Acetylprocainamide
目录号: PL05463 纯度: ≥98%
CAS No. :32795-44-1
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中文名称
N-Acetylprocainamide
中文别名
乙酰卡尼;N-乙酰基普鲁卡因胺;N-乙酰普鲁卡因胺;盐酸普鲁卡因胺杂质;盐酸茚丙胺;乙酰基普鲁卡因 标准品;乙酰普卡胺;N-Acetylprocainamide
英文名称
N-Acetylprocainamide
英文别名
Benzamide,4-(acetylamino)-N-[2-(diethylamino)ethyl]-;4-acetamido-N-[2-(diethylamino)ethyl]benzamide;N-Acetylprocainamide;4-acetamido-N-(2-diethylaminoethyl)benzamide;4-acetylamino-N-(2-diethylamino-ethyl)-benzamide;Acecainida;Acecainide;Acecainide [INN];Acecainidum;Acekainid;Acekainid [Polish];N-Acetylnovocainamide;N-Acetyloprokainamid;NAPA
Cas No.
32795-44-1
分子式
C15H23N3O2
分子量
277.36
包装储存
Powder -20°C 3 years;4°C 2 years
产品详情
N-Acetylprocainamide 是第三代抗心律失常剂,能够抑制 K+ 通道。
生物活性
N-Acetylprocainamide is a class III antiarrhythmic, which blocks K channels.
性状
Solid
IC50 & Target[1][2]
K channel
体外研究(In Vitro)
N-Acetylprocainamide is a K blocker. N-Acetylprocainamide decreases the tensions induced by K and methacholine. The pIC50 values for N-acetylprocainamide against the contractions induced by 0.3 and 1 μM methacholine are 2.80 ± 0.03 and 2.65 ± 0.02, respectively. And such a relaxant effect of N-Acetylprocainamide is inhibited by K channel blockers. N-Acetylprocainamide shows no effect on Na absorption or Cl secretion. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years;4°C 2 years
参考文献
[1]. Nakahara T, et al. Role of K+ channels in N-acetylprocainamide-induced relaxation of bovine tracheal smooth muscle. Eur J Pharmacol. 2001 Mar 9;415(1):73-8.
[2]. Plass H, et al. Class I antiarrhythmics inhibit Na+ absorption and Cl- secretion in rabbit descending colon epithelium. Naunyn Schmiedebergs Arch Pharmacol. 2005 Jun;371(6):492-9.
溶解度数据
In Vitro: DMSO : ≥ 100 mg/mL (360.54 mM)配制储备液
搜索质检报告(COA)

1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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