Cinoxacin|28657-80-9|(西诺沙星; Compound 64716)-陌孚医药/Medlife

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Cinoxacin (Synonyms: 西诺沙星; Compound 64716)

目录号: PL05454 纯度: ≥99%

CAS No. :28657-80-9

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中文名称	Cinoxacin
中文别名	西诺沙星;恶喹唑乙酸;新恶酸;西诺沙星标准品
英文名称	Cinoxacin
英文别名	cinoxacin;Cinoxacin [USAN:INN:BAN:JAN];(1,3)Dioxolo(4,5-g)cinnoline-3-carboxylic acid, 1-ethyl-1,4-dihydro-4-oxo-;1-Ethyl-1,4-dihydro-4-oxo(1,3)dioxolo(4,5-g)cinnoline-3-carboxylic acid;1-Ethyl-6,7-methylenedioxy-4(1H)-oxocinnoline-3-carboxylic acid;BRN 1084304;CCRIS 8206;Cinobac;Cinobactin;Cinoxacine;Cinoxacine [INN-French];Cinoxacino;Cinoxacino [INN-Spanish];Cinoxacinum;Cinoxacinum [INN-Latin];Compound 64716;Lilly 64716;NSC 304467;UNII-LMK22VUH23;Uronorm;(1,3)Dioxolo(4,5-g)cinnoline-3-carboxylic acid, 1,4-dihydro-1-ethyl-4-oxo-;1-ethyl-4-oxo-1,4-dihydro[1,3]dioxolo[4,5-g]cinnoline-3-carboxylic acid;1-ethyl-4-oxo-[1,3]dioxolo[4,5-g]cinnoline-3-carboxylic acid;1-ethyl-1,4-dihydro-4-oxo-{1,3}dioxolo{4,5:g}cinnoline-3-carboxylic acid;1-ethyl-4-oxo-1,4-dihydro-[1,3]dioxolo[4,5-g]cinnoline-3-carboxilic acid;Azolinic Acid;Clinoxacin
Cas No.	28657-80-9
分子式	C₁₂H₁₀N₂O₅
分子量	262.22
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	Cinoxacin (Compound 64716)，一种与喹诺酮类抗生素相关的口服抗菌剂。Cinoxacin 对许多革兰氏阴性需氧菌 (Gram-negative aerobic bacteria) 具有抗菌活性，并抑制细菌 DNA 的合成。Cinoxacin 可用于尿路感染和细菌性前列腺炎的研究。
生物活性	Cinoxacin (Compound 64716), a synthetic antimicrobial related to the quinolone class of orally active antibacterial agent. Cinoxacin has antibacterial activity against many gram-negative aerobic bacteria and inhibits bacterial DNA synthesis. Cinoxacin can be used for the research of urinary tract infections and bacterial prostatitis.
性状	Solid
IC50 & Target[1][2]	Quinolone
体外研究(In Vitro)	Cinoxacin (0-200μg/mL approximately, 3-24 h) inhibits many gram-negative aerobic bacteria with MIC values ranging from 4 to 64 μg/mL. has not independently confirmed the accuracy of these methods. They are for reference only.Cell Proliferation Assay
体内研究(In Vivo)	Cinoxacin (Oral administration, 1.7 g/kg, treated at 1 and 5 h postinfection) is effective in experimental bacterial infections in mice, with ED 50 values ranging from 8.1 to 58.6 mg/kg. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Scavone JM, et al. Cinoxacin: mechanism of action, spectrum of activity, pharmacokinetics, adverse reactions, and therapeutic indications. Pharmacotherapy. 1982 Sep-Oct;2(5):266-72. [2]. W E Wick, et al. Compound 64716, a new synthetic antibacterial agent. Antimicrob Agents Chemother. 1973 Oct;4(4):415-20.

溶解度数据	In Vitro: DMSO : 8.33 mg/mL (31.77 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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