Dapsone|80-08-0|(氨苯砜; 4,4′-Diaminodiphenyl sulfone; DDS)-陌孚医药/Medlife

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Dapsone (Synonyms: 氨苯砜; 4,4′-Diaminodiphenyl sulfone; DDS)

目录号: PL05394 纯度: ≥99%

CAS No. :80-08-0

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中文名称	Dapsone
中文别名	氨苯砜;4,4’-磺酰基双苯胺;4,4-二氨基苯砜;4,4-二氨二苯砜;4-氨基苯基砜;双（4-氨苯基）砜;双（4-氨基苯基）砜;4,4'-二氨基苯砜;4,4'-二氨基联苯砜;对氨基双苯砜;4,4ˊ-二氨基联苯砜;4,4`-二氨基二苯砜;醋氨苯砜;二乙酰氨苯砜;4,4'-二氨基二苯基砜;二氨基二苯砜;4,4`-磺酰基二苯胺;4,4’-二氨基二苯砜;4,4二氨基二苯砜;4,4''-二氨基二苯砜;4,4＇-二氨基二苯砜 USP标准品;4,4'-二氨基二苯砜（DDS）;4,4-二氨基二苯砜(DDS);4,4-二羟基二苯砜;4-氨基苯砜;Bis(4-aminophenyl) Sulfone ；双(4-氨苯基)砜;氨苯标准品;氨苯砜 EP标准品;氨苯砜标准品;4,4’-二氨基苯砜;4,4'-二氨基二苯砜;4,4-二氨基二苯砜;4,4'-磺酰基二苯胺;4-氨基苯基砜, 氨苯砜, 4,4′-磺酰基二苯胺,双（4-氨苯基）砜;医药中间体;治疗麻风病;4,4-二氨基苯砜;4,4′-磺酰基二苯胺;现货供应氨苯砜杂质ABCDE;二氨基二苯砜耐高温环氧树脂固化剂DDS;4,4-二氨基苯砜（DDS);4.4-二氨基二苯砜（DDS）;双(4-氨基苯基)砜
英文名称	Dapsone
英文别名	4-Aminophenyl sulfone;4,4-Sulfonyldianiline;DDS;4,4-Diaminodiphenyl sulfone;di(4-aminophenyl) sulphone;4,4-sulphonyldianiline;4-((4-aminophenyl)sulfonyl)phenylamine;Dapsone;4,4-Diaminodiphenyl sulphone;SULFONA-MAE;SULPHADIONE;TIMTEC-BB SBB003168;P-AMINOPHENYL SULFONE;NOVOPHONE;P,P'-SULFONYLDIANILINE;BIS(P-AMINOPHENYL)SULFONE;AVLOSULFON;4,4'-Diamino Diphenyl Sulfone;Bis(4-aminophenyl) Sulfone;4-(4-aminophenyl)sulfonylaniline;4-[(4-Aminophenyl)sulfonyl]aniline;4,4′-Diaminodiphenyl sulfone;4,4′-Sulfonyldianiline;4'4 DDS;Dapson;4,4'-Sulfonyldianiline;Dapsonum;4,4'-Diaminodiphenylsulfone;4,4'-Diaminodiphenyl Sulfone;Bis(4-aminophenyl)sulfone;Diaphenylsulfone;Diaphenylsulfon;Sulfona;Avlosulfone;Sulfadione;Diphenasone;Disulone;Udolac;DADPS;Croysulfone;Dumitone;Eporal;Diphone;Diaphenylsulphon;Metabolite C;Diaphenylsulphone;Sumicure S;Sulphonyldianiline;Dubronax;Croysulphone;Avlosulphone;Tarimyl;Aczone;Diaminodip;4,4'-Diaminodiphenyl sulfone
Cas No.	80-08-0
分子式	C₁₂H₁₂N₂O₂S
分子量	248.30
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	Dapsone (4,4′-Diaminodiphenyl sulfone) 是一种具有口服活性和血脑渗透通透性的磺酰类抗生素 (antibiotic)，具有抑菌、抗细菌和抗原虫活性。Dapsone 具有有效的抗麻风活性，抑制了麻风杆菌细胞提取物中叶酸的合成 (folate synthesis)。Dapsone 可用于皮肤病的研究，如麻风病、疱疹样皮炎、寻常痤疮等。
生物活性	Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al.
性状	Solid
IC50 & Target[1][2]	IC50: bacteriostatic; folate synthesis
体外研究(In Vitro)	Dapsone are added to cell lysates (100 μg of protein) and DHPS activity assay is tested. Dapsone exhibits an IC50 of 3.0 μg/ml for E. coli C600 in DHPS activity assay, but the growth of E. coli C600 is not inhibited at 256 μg/ml Dapsone. For the recombinant strain carrying M. leprae folP1 (pML101), Dapsone shows an IC50 of 0.06 μg/ml and a MIC of 1 μg/ml. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	In L. major-infected BALB/c MiceDapsone (topical treatment; 50 mg/kg; twice daily; 30 days) leads to sizes lesions around 186 mm compared to 125 mm for control mice. Furthermore, the amount of DAP quantified in the lesions treated with DAP cream is 9.6±8.5 μg of DAP/mg of skin. However, the number of parasites found in the spleen is significantly lower in mice treated with the cream than in non-treated mice. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Y I Zhu, et al. Dapsone and sulfones in dermatology: overview and update. J Am Acad Dermatol [2]. Dapsone, Drug.com [3]. D Voeller, et al. Interaction of Pneumocystis carinii dihydropteroate synthase with sulfonamides and diaminodiphenyl sulfone (dapsone).J Infect Dis. 1994 Feb;169(2):456-9.

溶解度数据	In Vitro: DMSO : 50 mg/mL (201.37 mM; ultrasonic and warming and heat to 60°C)配制储备液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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