Indinavir-d6|185897-02-3|(茚地那韦-d-陌孚医药/Medlife

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Indinavir-d6 (Synonyms: 茚地那韦-d

目录号: PL05397

CAS No. :185897-02-3

商品编号	规格	价格	会员价	是否有货	数量
PL05397-1mg	1mg	询价	询价
PL05397-10mg	10mg	询价	询价

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中文名称	Indinavir-d6
中文别名	茚地那韦-D6;(+)-诺卡酮;1-{4-苄基-2-羟基-5-[(2-羟基-2,3-二氢-1H-茚-1-基)氨基]-5-氧代戊基}-N-(2-甲基-2-丙基)-4-[(2H4)-3-吡啶基(2H2)甲基]-2-哌嗪甲酰胺
英文名称	Indinavir-d6
英文别名	D-erythro-Pentonamide,2,3,5-trideoxy-N-[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]-5-[(2S)-2-[[(1,1-dimethylethyl)amino]carbonyl]-4-(3-pyridinyl-2,4,5,6-d4-methyl)-1-piperazinyl]-2-(phenylmethyl)-(9CI);Indinavir-D-6;(2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-oxopentyl]-N-tert-butyl-4-[dideuterio-(2,4,5,6-tetradeuteriopyridin-3-yl)methyl]piperazine-2-carboxamide;D-erythro-Pentonamide,2,3,5-trideoxy-N-[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]-5-[(2S)-2...;D-erythro-Pentonamide,2,3,5-trideoxy-N-[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]-5-[(2S)-2-[[(1,1-dimethylethyl)amino]car;D-erythro-Pentonamide,2,3,5-trideoxy-N-[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]-5-[(2S)-2-[[(1,1-dimethylethyl)amino]carbonyl]-4-(3-pyridinyl-2,4,5,6-d4-methyl)-1-piperazinyl]-2-(phenylmethyl)-(9;INDINAVIR-D6;2,3,5-Trideoxy-N-[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]-5-[(2S)-2[[(1,1-dimethylethyl)amino]carbonyl]-4-(3-pyridinylmethyl-d6)-1-piperazinyl]-2-(phenylmethyl)-D-erythro-pentonamide
Cas No.	185897-02-3
分子式	C₃₆H₄₇N₅O₄
分子量	613.79
包装储存	Please store the product under the recommended conditions in the Certificate of Analysis.

产品详情	Indinavir-d₆ 是 Indinavir 的氘代物。Indinavir(MK-639; L735524)是HIV蛋白酶抑制剂，具有很好的口服生物相容性。
生物活性	Indinavir-d 6 is the deuterium labeled Indinavir. Indinavir (MK-639; L735524) is a potent and specific HIV protease inhibitor that appears to have good oral bioavailability.
体外研究(In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Stein, D.S., et al., A 24-week open-label phase I/II evaluation of the HIV protease inhibitor MK-639 (indinavir). AIDS, 1996. 10(5): p. 485-92. [3]. Liu, F., et al., Kinetic

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