Teprenone|6809-52-5|(替普瑞酮; Geranylgeranylacetone)-陌孚医药/Medlife

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Teprenone (Synonyms: 替普瑞酮; Geranylgeranylacetone)

目录号: PL05407 纯度: ≥98%

CAS No. :6809-52-5

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中文名称	Teprenone
中文别名	替普瑞酮;戊四烯酮;6,10,14,18-四甲基-5,9,13,17-十九碳四烯-2-酮;替普瑞酮[(5E,9E,13E)- 和(5Z,9E,13E)异构体混和物];Teprenone [mixture of (5E,9E,13E)- and (5Z,9E,13E)- isomers] 替普瑞酮[(5E,9E,13E)- 和(5Z,9E,13E)异构体混和物];全反式泰普瑞浓;替普瑞酮F·S;替普瑞酮标准品(JP);6,10,14,18-四甲基-5,9,13,17-十九碳四烯-2-酮 [(5E,9E,13E)- 和(5Z,9E,13E)异构体混合物];戊四烯酮 [(5E,9E,13E)- 和(5Z,9E,13E)异构体混合物]
英文名称	Teprenone
英文别名	Teprenone;6,10,14,18-Tetramethyl-5,9,13,17-nonadecatetraen-2-one;Teprenone [mixture of (5E,9E,13E)- and (5Z,9E,13E)- isomers];Geranylgeranylacetone;6,10,14,18-Tetramethyl-5,9,13,17-nonadecatetraen-2-one, mixture of (5E,9E,13E) and (5Z,9E,13E) isomers;GGA;Selbex;UNII-S8S8451A4O;Geranylgeranylacetone [mixture of (5E,9E,13E)- and (5Z,9E,13E)- isomers];6,10,14,18-Tetramethyl-5,9,13,17-nonadecatetraen-2-one [mixture of (5E,9E,13E)- and (5Z,9E,13E)- isomers];DSSTox_RID_82818;DSSTox_CID_28546;DSSTox_GSID_48620;Tox21_112960;(9E,13E)-6,10,14,18-Tetramethylnonadeca-5,9,13,17-tetraen-2-one;T2701
Cas No.	6809-52-5
分子式	C₂₃H₃₈O
分子量	330.55
包装储存	4°C, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

产品详情

Teprenone 是一种抗溃疡药，为热休克蛋白 (heat shock proteins) 的诱导剂。

生物活性

Teprenone is an anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs).

性状

Liquid

IC50 & Target[1][2]

HSP

体外研究(In Vitro)

Teprenone is an inducer of HSPs. Teprenone (Geranylgeranylacetone, 1 μM) significantly prevents ethanol-induced exfoliation, and reduces lactate dehydrogenase (LDH) release in gastric mucosal cells. Teprenone (1 μM) gradually increases HSC70 level, and rapidly accumulates the stress-inducible HSP90, HSP70, and HSP60 concentrations within 30-60 min. Teprenone also activates the heat shock factor 1. Teprenone (0-20 μM) slightly increases human umbilical vein endothelial cell (HUVEC) viability following irradiation (IR). Teprenone (10 μM) exhibits no effects on HUVEC migration and invasion, but enhances HUVEC tube formation and wound healing both with and without IR. Teprenone (10 μM) also promotes angiogenesis by inducing VEGF and eNOS expression in HUVECs. has not independently confirmed the accuracy of these methods. Th

体内研究(In Vivo)

Teprenone (200 mg/kg, p.o.) results in the accumulation of HSP70 mRNA in rats, and the accumulation is enhanced by stress addition in the mucosa of Teprenone-pretreated rats compared with that of vehicle-pretreated rats. Teprenone (200 mg/kg, p.o.) markedly suppresses the ulcer formation after 2- and 4-hour stress loading in rats. Teprenone (200 mg/kg daily) induces HSP72 in retinal ganglion cells (RGCs) from rat retinas. Teprenone significantly reduces the loss of RGCs (evaluated after intraocular pressure (IOP) elevation), lessens optic nerve damage, decreases the number of TUNEL-positive cells in the RGC layer, and increases HSP72 in a rat model of glaucoma. Teprenone (200 mg/kg, p.o.) shows protective effect on radiation-induced intestinal injury in mice. has not independently confirmed the accuracy of these methods

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

ClinicalTrial

参考文献

[1]. Hirakawa T, et al. Geranylgeranylacetone induces heat shock proteins in cultured guinea pig gastric mucosal cells and rat gastric mucosa. Gastroenterology. 1996 Aug;111(2):345-57.
[2]. Caprioli J, et al. Retinal ganglion cell protection with geranylgeranylacetone, a heat shock protein inducer, in a rat glaucoma model. Trans Am Ophthalmol Soc. 2003;101:39-50; discussion 50-1.

溶解度数据	In Vitro: DMSO : 100 mg/mL (302.53 mM; Need ultrasonic)Ethanol : 50 mg/mL (151.26 mM; Need ultrasonic)配制储备液

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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