Dapsone-d4|1346602-12-7|(4,4′-Diaminodiphenyl sulfone-d-陌孚医药/Medlife

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Dapsone-d4 (Synonyms: 4,4′-Diaminodiphenyl sulfone-d

目录号: PL05396

CAS No. :1346602-12-7

商品编号	规格	价格	会员价	是否有货	数量
PL05396-1mg	1mg	询价	询价
PL05396-10mg	10mg	询价	询价

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中文名称	Dapsone-d4
中文别名	[2H4]-氨苯砜;氨苯砜 D4
英文名称	Dapsone-d4
英文别名	DAPSONE-D4;1,1'-Sulfonylbis[4-aMinobenzene]-d4;4,4'-DiaMinodiphenyl Sulfo;DADPS-d4, DDS-d4, Avlosulfon-d4, Croysulfone-d4, Diphenasone-d4, Disulone-d4, DuMitone-d4, Eporal-d4, Novophone-d4, Sulfona-Mae-d4, Sulphadione-d4, 4,4'-SulfonylbisbenzeneaMine-d4;[2H4]-Dapsone;Dapsone D4Q: What is Dapsone D4 Q: What is the CAS Number of Dapsone D4 Q: What is the storage condition of Dapsone D4 Q: What are the applications of Dapsone D4
Cas No.	1346602-12-7
分子式	C₁₂H₁₂N₂O₂S
分子量	248.30
包装储存	Please store the product under the recommended conditions in the Certificate of Analysis.

产品详情	Dapsone-d₄ 是 Dapsone 的氘代物。Dapsone (4,4′-Diaminodiphenyl sulfone) 是一种具有口服活性和血脑渗透通透性的磺酰类抗生素 (antibiotic)，具有抑菌、抗细菌和抗原虫活性。Dapsone 具有有效的抗麻风活性，抑制了麻风杆菌细胞提取物中叶酸的合成 (folate synthesis)。Dapsone 可用于皮肤病的研究，如麻风病、疱疹样皮炎、寻常痤疮等。
生物活性	Dapsone-d 4 is the deuterium labeled Dapsone. Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities[1]. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al[2][3].
体外研究(In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Y I Zhu, et al. Dapsone and sulfones in dermatology: overview and update. J Am Acad Dermatol [3]. Dapsone, Drug.com

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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