Loxoprofen|68767-14-6|(洛索洛芬)-陌孚医药/Medlife

您当前的位置：

Loxoprofen (Synonyms: 洛索洛芬)

目录号: PL05370 纯度: ≥99%

CAS No. :68767-14-6

商品编号	规格	价格	会员价
PL05370-10mg	10mg	¥618.18	请登录
PL05370-50mg	50mg	¥865.45	请登录
PL05370-100mg	100mg	¥1224.00	请登录
PL05370-200mg	200mg	¥1483.64	请登录
PL05370-500mg	500mg	询价	询价
PL05370-1g	1g	询价	询价
PL05370-10mM*1mLinDMSO	10mM*1mLinDMSO	¥680.00	请登录

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称	Loxoprofen
中文别名	洛索洛芬;DL-3-氯丝氨酸甲酯盐酸盐;氯索洛芬;洛索洛芬,Loxoprofen;洛索洛芬标准品(JP);洛索洛芬钠中间体;洛索洛芬酸;2-[4-(2-氧代环戊烷-1-基甲基)苯基]丙酸;Α-甲基-4-[(2-氧代环戊基)甲基]苯乙酸钠;环氧洛芬;洛索洛芬钠;2-[4-[(2-氧代环戊基)甲基]苯基]丙酸
英文名称	Loxoprofen
英文别名	2-(4-((2-Oxocyclopentyl)methyl)phenyl)propanoic acid;2-{4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid;ALPHA-METHYL-4-[(2-OXOCYCLOPENTYL)METHYL]BENZENEACETIC ACID;KOLOXO;2-[4-(2-OXO-CYCLOPENTYLMETHYL)-PHENYL]-PROPIONIC ACID;A-METHYL-4-[(2-OXOCYCLOPENTYL)METHYL]BENZENEACETIC ACID;α-methyl-4-[(2-oxocyclopentyl)methyl]benzeneacetic acid;IOXOPROFEN;2-[4-[(2-Oxocyclopentan-1-yl)methyl]phenyl]propionic acid;Loxoprofen acid;Loxoprofen;2-(4-((2-Oxocyclopentyl)methyl)-phenyl)propanoic acid;Loxoprofen See L472900;2-[4-[(2-Oxocyclopentyl)methyl]phenyl]propionic Acid;Loxoprofeno;Loxoprofene;sodium loxoprofen;Loxoprofenum;Loxoprofen [INN];Loxoprofene [French];Loxoprofenum [Latin];Loxoprofeno [Spanish];yl]-propionic acid;2-[4-(2-Oxo-cyclopentylmethyl)-phen;2-[4-[(2-oxocyclopentyl)methyl]phenyl]propanoic acid;Loxoprofen sodium hydrate;YMBXTVYHTMGZDW-UHFFFAOYSA-N;Loxoprofen (INN);Oxeno;α-Methyl-4-[(2-oxocyclopentyl)methyl]benzeneacetic acid;Koloxo;2-{4-[(2-Oxocyclopentyl)methyl]phenyl}propanoic acid
Cas No.	68767-14-6
分子式	C₁₅H₁₈O₃
分子量	246.30
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情

Loxoprofen 是一种具有口服活性和解热作用的非甾体类抗炎药，可用于缓解疼痛的研究。Loxoprofen 是一种非选择性 COX 抑制剂，对 COX-1 和 COX-2 的 IC₅₀ 分别为 6.5 和 13.5 μM。Loxoprofen 可降低动脉粥样硬化，并具有抗肿瘤活性。

生物活性

Loxoprofen is a non-steroidal, orally active anti-inflammatory agent with analgesic and anti-pyretic properties. Loxoprofen is a nonselective COX inhibitor with IC 50 s of 6.5 and 13.5 μM for COX-1 and COX-2, respectively. Loxoprofen can reduce atherosclerosis and shows antitumor activity.

性状

Solid

IC50 & Target[1][2]

COX-1 6.5 μM (IC50, in human whole blood) COX-2

体外研究(In Vitro)

Loxoprofen, an anti-inflammatory prodrug (NSAID), is a nonselective COX inhibitor with IC50s of 6.5 and 13.5 μM for COX-1 and COX-2 in human whole blood assays, respectively.
Loxoprofen (LOX) is a non-selective cyclooxygenase inhibitor that is widely used for the reasearch of pain and inflammation caused by chronic and transitory conditions. Its alcoholic metabolites are formed by carbonyl reductase (CR) and they consist of trans-LOX, which is active, and cis-LOX, which is inactive. In addition, LOX can also be converted into an inactive hydroxylated metabolite (OH-LOXs) by cytochrome P450 (CYP). has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Loxoprofen sodium (4 mg/kg/day; p.o.; 1 or 8 weeks) reduces atherosclerosis in mice by reducing inflammation. Loxoprofen sodium (60 μg/mL; p.o.; 24 days) suppresses mouse tumor growth by inhibiting VEGF. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；4°C 2 years

ClinicalTrial

参考文献

[1]. Riendeau D, et al. Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2. Bioorg Med Chem Lett. 2004;14(5):1201-1203.
[2]. Paudel S, et al. Assessing Drug Interaction and Pharmacokinetics of Loxoprofen in Mice Treated with CYP3A Modulators. Pharmaceutics. 2019;11(9):479. Published 2019 Sep 16.

溶解度数据	In Vitro: DMSO : ≥ 100 mg/mL (406.01 mM)配制储备液

搜索质检报告(COA)

产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

相关产品

The molarity calculator equation

The dilution calculator equation