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| 中文名称 |
Trimethoprim-d3
|
|---|---|
| 中文别名 |
甲氧苄啶-D3;TrimethoprimD3(4-methoxyD3) 标准品;甲氧苄氨嘧啶-d3(4-甲氧基-d3);甲氧苄啶 d3
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| 英文名称 |
Trimethoprim-d3
|
| 英文别名 |
Trimethoprim-d3;5-[[3,5-dimethoxy-4-(trideuteriomethoxy)phenyl]methyl]pyrimidine-2,4-diamine;Instalac-d3;Monotrim-d3;Proloprim-d3;Syraprim-d3;Tiempe-d3;Trimanyl-d3;Uretrim-d3;Wellcoprim-d3;Trimethoprim D3 (4-methoxy D3);[2H3]-Trimethoprime;2,4-Diamino-5-(3',4',5'-trimethoxy-d3-benzyl)pyrimidine;5-[(3,4,5-Trimethoxy-d3-phenyl)methyl]-2,4-pyrimidinediamine;5-({3,5-Dimethoxy-4-[(~2~H_3_)met
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| Cas No. |
1189923-38-3
|
| 分子式 |
C14H18N4O3
|
| 分子量 |
293.34
|
| 包装储存 |
Powder -20°C 3 years；4°C 2 years
|
| 产品详情 |
Trimethoprim-d3 是 Trimethoprim 的氘代物。Trimethoprim 是一种抑菌抗生素，也是一种具有口服活性的二氢叶酸还原酶 (dihydrofolate reductase) 抑制剂。Trimethoprim 对多种革兰氏阳性和革兰氏阴性需氧细菌 (Gram-positive 和 Gram-negative aerobic bacteria) 具有活性。Trimethoprim 可用于尿路感染，志贺氏菌病和肺孢子菌肺炎的研究。
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|---|---|
| 生物活性 |
Trimethoprim-d 3 is the deuterium labeled Trimethoprim. Trimethoprim is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim has the potential for urinary tract infections, Shigellosis and Pneumocystis pneumonia treatment[1][2][3].
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| 性状 |
Solid
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| 体外研究(In Vitro) |
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. has not independently confirmed the accuracy of these methods. They are for reference only.
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
Powder -20°C 3 years；4°C 2 years
|
| 参考文献 |
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Laskowska, E., et al., Trimethoprim induces heat shock proteins and protein aggregation in E. coli cells. Curr Microbiol, 2003. 47(4): p. 286-9.;Brogden, R.N., et al., Trimethoprim: a review of its antibacterial activity, pharmacokinetics and therapeutic
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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。
2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。
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