购物车0
产品总数：60950
| 中文名称 |
Bupivacaine hydrochloride
|
|---|---|
| 中文别名 |
盐酸布比卡因;1-丁基-N-(2,6-二甲基苯基)哌啶-2-甲酰胺 盐酸盐;Bupivacaine Hydrochloride 盐酸布比卡因;DL-色氨酸乙酯盐酸盐;布比卡因盐酸盐;1-丁基-N-(2,6-二甲基苯基)哌啶-2-甲酰胺盐酸盐
|
| 英文名称 |
Bupivacaine hydrochloride
|
| 英文别名 |
2-Piperidinecarboxamide,1-butyl-N-(2,6-dimethylphenyl)-, hydrochloride (1:1);Bupivacaine Hydrochloride;Bupivacaine HCl;Bupivacaine (hydrochloride);1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide monohydrochloride;1-Butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Hydrochloride;1-butyl-piperidine-2-car;2',6'-Pipecoloxylidide,1-butyl-,monohydrochloride;Bicain;BUPIVACAINE HYDROCHLORIDE ANHYDROUS;Bupivacaine hydrochloride(Marcain);Einecs 241-917-8;Marcain;Marcaina;2',6'-Pipecoloxylidide, 1-butyl-, hydrochloride (6CI);bupivacaine;1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide;DL-Bupivacaine;Marcaine;Carbostesin;Bupivacaina;Bupivacainum;Anekain;(+-)-Bupivacaine;Sensorcaine;1-Butyl-2',6'-pipecoloxylidide;Bupivacainum [INN-Latin];Bupivacaina [INN-Spanish];dl-1-Butyl-2',6'-pipecoloxylidide;cBupivacaine;Bloqueina;2-Piperidinecarboxamide, 1-butyl-N-(2,6-dimethylphenyl)-;Win 11318;Bupivacaine HCL KIT;(+/-)-Bupivacaine;bupivacaine base;1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamid;2',6'-Pipecoloxylidide, 1-butyl-, monohydrochloride
|
| Cas No. |
18010-40-7
|
| 分子式 |
C18H28N2O
|
| 分子量 |
288.43
|
| 包装储存 |
4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
|
| 产品详情 |
Bupivacaine hydrochloride 是一种 NMDA 受体抑制剂。Bupivacaine 可以阻断钠、L-钙和钾通道。Bupivacaine 有效阻断 SCN5A 通道，IC50 为 69.5 μM。Bupivacaine hydrochloride 可用于慢性疼痛的研究。
|
|---|---|
| 生物活性 |
Bupivacaine hydrochloride is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC 50 of 69.5 μM. Bupivacaine hydrochloride can be used for the research of chronic pain.
|
| 性状 |
Solid
|
| IC50 & Target[1][2] |
Sodium Channel
|
| 体外研究(In Vitro) |
Bupivacaine hydrochloride inhibits NMDA receptor-mediated synaptic transmission in the dorsal horn of the spinal cord, an area critically involved in central sensitization. Bupivacaine hydrochloride influences the voltage dependency of channel activation and steady-state inactivation by shifting the membrane potential of half-maximal activation/inactivation toward somewhat more negative membrane potentials. In their inactivated state, SCN5A channels are slightly sensitive toward Bupivacaine hydrochloride IC50=2.18±0.16 μM. Bupivacaine hydrochloride reversibly inhibits the SK2 channel in a dose-dependent manner with the IC 50 of 16.5 μM. has not independently confirmed the accuracy of these methods. They are for reference only.
|
| 运输条件 |
Room temperature in continental US; may vary elsewhere.
|
| 储存方式 |
4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
|
| ClinicalTrial |
|
| 参考文献 |
[1]. Casati A, et, al. Bupivacaine, levobupivacaine and ropivacaine: are they clinically different? Best Pract Res Clin Anaesthesiol. 2005 Jun;19(2):247-68.[2]. Dan J, et, al. Inhibition of gastric cancer by local anesthetic bupivacaine through multiple mechanisms independent of sodium channel blockade. Biomed Pharmacother. 2018 Jul;103:823-828.
|
| 溶解度数据 |
In Vitro: DMSO : 25 mg/mL (76.95 mM; Need ultrasonic)H2O : 12.5 mg/mL (38.47 mM; Need ultrasonic)配制储备液
|
|---|
1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。
2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。
Copyright © 2025 陌孚医药 All rights reserved 未经授权禁止拷贝本站所有资料，如有违反，将追究法律责任。
沪ICP备2023012080号 | 
沪公网安备31011402010657号
扫码关注公众号
产品使用指南
