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| 中文名称 |
Phenylbutazone(diphenyl-d10)
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|---|---|
| 中文别名 |
保泰松-D10氘代内标;保泰松-D10;苯基butazone-d10(二苯基-d10);保泰松 d10
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| 英文名称 |
Phenylbutazone(diphenyl-d10)
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| 英文别名 |
Phenylbutazone-d10 (diphenyl-d10);phenylbutazone;4-Butyl-1,2-diphenylpyrazolidine-3,5-dione;Butazolidine;Fenilbutazona;Phenylbutazonum;Butazolidin;Diphenylbutazone;Butapirazol;Butapyrazole;Butacote;Butadion;Azolid;Bute;Alkabutazona;Butapirazole;Chembutazone;Fenibutazona;Fenylbutazon;Intrabutazone;Mephabutazon;Mephabutazone;Phenylbutazon;Praecirheumin;Scanbutazone;Alqoverin;Anpuzone;Anuspiramin;Arthrizon;Artrizin;Artrizone;Artropan;Azobutyl;Bunetzone;Butacompren;Butadiona;Butagesic;Butalgina;Butalidon;Butarecbon;Butartril;Phenylbutazone(diphenyl-d10)
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| Cas No. |
1219794-69-0
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| 分子式 |
C19H20N2O2
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| 分子量 |
308.37
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| 包装储存 |
Powder -20°C 3 years；4°C 2 years
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| 产品详情 |
Phenylbutazone(diphenyl-d10) 是 Phenylbutazone 的氘代物。Phenylbutazone 是有效的前列腺素 H 合酶 (PHS) 过氧化物酶的还原辅助因子。Phenylbutazone 是一种肝毒素，是非甾体类抗炎药 (NSAID)。Phenylbutazone 诱导肌肉盲样蛋白1 (MBNL1) 表达，有用于强直性脊柱炎研究的潜力。
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| 生物活性 |
Phenylbutazone(diphenyl-d 10 ) is the deuterium labeled Phenylbutazone. Phenylbutazone is an efficient reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS). Phenylbutazone, a hepatotoxin, is a nonsteroidal anti-inflammatory drug (NSAID). Phenylbutazone induces muscle blind-like protein 1 (MBNL1) expression and has the potential for ankylosing spondylitis research[1][2].
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| 性状 |
Solid
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| 体外研究(In Vitro) |
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. has not independently confirmed the accuracy of these methods. They are for reference only.
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
Powder -20°C 3 years；4°C 2 years
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| 参考文献 |
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.[2]. G A Reed, et al. Inactivation of prostaglandin H synthase and prostacyclin synthase by phenylbutazone. Requirement for peroxidative metabolism. Mol Pharmacol. 1985 Jan;27(1):109-14.
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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。
2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。
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