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产品总数：60943
| 中文名称 |
Disulfiram
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|---|---|
| 中文别名 |
促进剂TETD;双(二乙基硫代氨基甲酰)二硫化物;戒酒硫;1,1'-二硫双(N,N-二乙基硫代甲酰胺);双硫仑;二磺法胺;二硫化四乙基秋兰姆;四乙基二硫化秋兰姆;双硫伦;四乙基硫代过氧化二碳酸二酰胺;四乙基秋兰姆二硫化物;二硫龙;二硫化双(二乙硫代氨甲酰);二硫化啡喃;二硫化四乙基硫尿;醇去氢酶,;Tetraethylthiuram Disulfide 二硫化四乙基秋兰姆;促进剂TETD-75;促进剂TETD双(二乙基硫代氨基甲酰)河南荣欣鑫科技;二硫化四乙基秋兰姆 USP标准品;二硫化四乙基秋兰姆（促进剂TETD）;鹤壁联昊促进剂TETD;黄岩促进剂TETD;戒酒硫 EP标准品;双硫仑 标准品;双硫仑-D20;橡胶促进剂TETD;橡胶预分散促进剂TETD-75;橡胶硫化促进剂 TETD;二硫化双荒酰二乙胺;双(二乙硫代氨基甲酰)二硫化物;双硫仑(双硫醒);双硫伦,双硫醒;双硫伦,双硫醒, 戒酒硫;双硫醒;硫化四乙基秋兰姆
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| 英文名称 |
Disulfiram
|
| 英文别名 |
Tetraethylthiuram disulfide;TETD;bis(diethylthiocarbamoyl) disulfide;disulfiram;tetraethylthiuram disulphide;accelerator tetd;bis (diethylthiocarbamyl) disulfide;ethylthiudad;ethyltuex;etyl tuex;exhoran;exhorran;formamide, 1,1'-dithiobis(n,n-diethylthio)-;hoca;hocakrotenalnci-c02959;hydrogendisulfide;hydrogenpersulfid;krotenal;n,n,n',n'-tetraethylthiuram disulfide;n,n,n',n'-tetraethylthiuram disulphide;nci-c02959;nocbin;nsc 190940;perkacit tetd;perkait tetd;1,1',1'',1'''-{Disulfanediylbis[(thioxomethylene)-nitrilo]}tetraethane;1,1-Dithiobis(N,N-diethylthioformamide);1,1`-Dithiobis(N,N-diethylthioformamide);Abstenisil;N1,N1,N3,N3-tetraethyl-2-dithioperoxy-1,3-dithiodicarbonic diamide;Tetraethylthioperoxydicarbonic diaMide;tetraethylthioperoxydicarbonic diamide ([[(C2H5)2N]C(S)]2S2);TTD;Antabuse;Antabus;Teturam;Esperal;Anticol;Alcophobin;Dicupral;Ethyldithiurame;Teturamin;Tetraetil;Contralin;Antietanol;Antaethyl;Tetradine;Antivitium;Abstensil;Aversan;Abstinil;Refusal;Averzan;Antetil;Antetan;Abstinyl;Antalcol;Antadix;Cronetal;Antikol;Antietil;Etabus;Ethyl tuads;Ethyl Thiurad;Ethyl Thiram;Ethyl Tuex;Disulfuram;Contrapot;Antiaethan;Stopetyl;Thiuranide;Ephorran;Antaetil;Di;Disulfide, bis(diethylthiocarbamoyl) (8CI);N,N,N′,N′-Tetraethylthioperoxydicarbonic diamide ([(H2N)C(S)]2S2) (ACI);Thioperoxydicarbonic diamide ([(H2N)C(S)]2S2), tetraethyl- (9CI);Accel TET;Accel TET-R;Accelerator TET;Akrochem TETD;Bis(diethylthiocarbamoyl) disulfide;Bis(N,N-diethylthiocarbamoyl) disulfide;Curebead PB 75;Curekind TETD;Disulfiram;Ekagom DTET;Ekagom TEDS;Ekagom TETDS;Espenal;Ethyl Tuads;Etiltox;Exhoran;Exhorran;Hoca;Krotenal;N,N,N′,N′-Tetraethyldithiuram disulfide;N,N,N′,N′-Tetraethylthiuram disulfide;Bis(diethylthiocarbamoyl) Disulfide
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| Cas No. |
97-77-8
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| 分子式 |
C10H20N2S4
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| 分子量 |
296.54
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| 包装储存 |
Powder -20°C 3 years；4°C 2 years
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| 产品详情 |
Disulfiram (Tetraethylthiuram disulfide) 是特异性的乙醛脱氢酶 1 型 (ALDH1) 抑制剂，对酒精具有急性敏感性。Disulfiram 有效抑制人体和小鼠细胞中脂质体中的 GSDMD 孔形成，炎性体介导的细胞凋亡和 IL-1β 分泌。双硫仑 + Cu2+ 可增加细胞内 ROS 水平，引发卵巢癌干细胞凋亡。
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| 生物活性 |
Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells. Disulfiram?+?Cu increases intracellular ROS levels triggering apoptosis of ovarian cancer stem cells.
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| 性状 |
Solid
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| IC50 & Target[1][2] |
IL-1 IL-1β
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| 体外研究(In Vitro) |
Disulfiram-copper complex potently inhibits the proteasomal activity in cultured breast cancer MDA-MB-231 and MCF10DCIS.com cells, but not normal, immortalized MCF-10A cells, before induction of apoptotic cancer cell death. Disulfiram (DS), a clinically used anti-alcoholism drug, strongly inhibits constitutive and 5-FU-induced NF-kappaB activity in a dose-dependent manner. Disulfiram inhibits both NF-kappaB nuclear translocation and DNA binding activity but has no effect on 5-FU-induced IkappaBalpha degradation. Disulfiram significantly enhances the apoptotic effect of 5-FU on DLD-1 and RKO(WT) cell lines and synergistically potentiated the cytotoxicity of 5-FU to both cell lines. Disulfiram also effectively abolishes 5-FU chemoresistance in a 5-FU resistant cell line H630(5-FU) in vitro. Oseltamivir decreases the number of viable cells, and the addition of CuCl2
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| 体内研究(In Vivo) |
Disulfiram significantly inhibits the tumor growth (by 74%), associated with in vivo proteasome inhibition (as measured by decreased levels of tumor tissue proteasome activity and accumulation of ubiquitinated proteins and natural proteasome substrates p27 and Bax) and apoptosis induction (as shown by caspase activation and apoptotic nuclei formation) in mice bearing MDA-MB-231 tumor xenografts. Disulfiram blocks the P-glycoprotein extrusion pump, inhibits the transcription factor nuclear factor-kappaB, sensitizes tumors to chemotherapy, reduces angiogenesis, and inhibits tumor growth in mice. Disulfiram inhibits growth and angiogenesis in melanomas transplanted in severe combined immunodeficient mice, and these effects are potentiated by Zn supplementation. has not independently confirmed the accuracy of these met
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
Powder -20°C 3 years；4°C 2 years
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| ClinicalTrial |
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| 参考文献 |
[1]. Chen D, ert al. Disulfiram, a clinically used anti-alcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and?xenografts?via?inhibition?of the proteasome?activity. Cancer Res. 2006 Nov 1;66(21):10425-33.[2]. Wang W, et al. Disulfiram-mediated inhibition of NF-kappaB activity enhances cytotoxicity of 5-fluorouracil in human colorectal cancer cell lines. Int J Cancer. 2003 Apr 20;104(4):504-11.
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| 溶解度数据 |
In Vitro: DMSO : 75 mg/mL (252.92 mM; Need ultrasonic)配制储备液
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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。
2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。
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