Estrone-d4 (Synonyms: 雌酮-d
目录号: PL05298 纯度: ≥99%
CAS No. :53866-34-5
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中文名称
Estrone-d4
中文别名
雌酮-D4;雌酚酮-2,4,16,16-d4;2,4-二溴联苯;雌酮-2,4,16,16-d4;氘代雌酮;雌激素酮-d4
英文名称
Estrone-d4
英文别名
Estra-1,3,5(10)-trien-17-one-2,4,16,16-d4,3-hydroxy-;Estrone-2,4,16,16-d4;Estrone-d4;2,4,16,16-D4-estrone;Aquacrine-d4;Crinovaryl-d4;Cristallovar-d4;Crystogen-d4;E1-2,4,16,16-d4;Wynestron-d4
Cas No.
53866-34-5
分子式
C18H22O2
分子量
270.37
包装储存
Powder -20°C 3 years;4°C 2 years
产品详情
Estrone-d4 是一种氘代标记的 Estrone。Estrone (E1) 是一种天然的雌激素。Estrone 是内源性雌激素的主要代表,由多种组织产生,尤其是脂肪组织。Estrone 是脂肪细胞中雄烯二酮芳构化过程的结果。
生物活性
Estrone-d 4 is the deuterium labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells[1][2].
性状
Solid
体外研究(In Vitro)
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years;4°C 2 years
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
[2]. Caupos E, et al. Photodegradation of estrone enhanced by dissolved organic matter under simulated sunlight. Water Res. 2011;45(11):3341-3350.
[3]. de Padua Mansur A, et al.
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1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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