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产品总数：60950
| 中文名称 |
Amlodipine maleate
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|---|---|
| 中文别名 |
马来酸氨氯地平;甲磺酸氨氯地平;马来酸氨氯地平 标准品;马来酸氨氯地平对照品
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| 英文名称 |
Amlodipine maleate
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| 英文别名 |
Amlodipine maleate;3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate maleate;Amlodipine (maleate);(3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chloro;2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester;2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester (z)-2-butenedioate;3-ethyl-5-methyl-(4-RS)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate maleate;Amvaz;Amlodipine maleate [USAN];Amlodipine (+-)-form maleate;C20H25ClN2O5.C4H4O4;Amlodipine maleate (USAN);3-Ethyl 5-methyl (+-)-2-((2-aminoethoxy)methyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate, maleate (1:1);AmlodipineMaleate;3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (+-)-, (Z)-2-butenedioate (1:1);(Z)-but-2-enedioic acid;3-O
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| Cas No. |
88150-47-4
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| 分子式 |
C24H29ClN2O9
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| 分子量 |
524.95
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| 包装储存 |
4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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| 产品详情 |
Amlodipine maleate 是二氢吡啶类钙通道 (calcium channel) 阻滞剂，作为一种具有口服活性的抗心绞痛试剂 (antianginal agent)。Amlodipine maleate 阻断了电压依赖性的 L 型钙通道，从而抑制了钙离子内流。Amlodipine maleate 可用于高血压和癌症的研究。
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| 生物活性 |
Amlodipine maleate is a dihydropyridine calcium channel blocker, acts as an orally active antianginal agent. Amlodipine maleate blocks the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine maleate can be used for the research of high blood pressure and cancer.
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| 性状 |
Solid
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| IC50 & Target[1][2] |
L-type calcium channel
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| 体外研究(In Vitro) |
Amlodipine maleate (20-40 μM; 48 h) reduces BrdU incorporation to 68.6% and 26.3% at concentrations of 20 and 30 μM in A431 cells, respectively.Amlodipine maleate (30 μM; pretreated for 1 h) significantly attenuates the uridine 5′-triphosphate (UTP)-induced increases of [Ca]i in A431 cells.Amlodipine maleate (30 μM) inhibits the store-operated Cainflux evoked by Thapsigargin in Fluo-3-loaded cells. has not independently confirmed the accuracy of these methods. They are for reference only.
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| 体内研究(In Vivo) |
Amlodipine maleate (5 mg/kg/day; s.c. for 2 weeks) significantly decreases systolic blood pressure (SBP) in VSMC ATP2B1 KO mice.
Amlodipine maleate (10 mg/kg; i.p. once daily for 20 days) causes a significant retardation of tumor growth and prolongs the survival of A431 tumor-bearing mice. has not independently confirmed the accuracy of these methods. They are for reference only.
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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| ClinicalTrial |
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| 参考文献 |
[1]. Kishen G. Bulsara, et al. Amlodipine.[2]. Haria M, et al. Amlodipine. A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disease [published correction appears in Drugs 1995 Nov;50(5):896]. Drugs. 1995;50(3):560-586.[3]. Yoshida J, et, al. Antitumor effects of amlodipine, a Ca2+ channel blocker, on human epidermoid ca
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| 溶解度数据 |
In Vitro: DMSO : 120 mg/mL (228.59 mM; Need ultrasonic)配制储备液
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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。
2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。
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