Dorzolamide hydrochloride|130693-82-2|(盐酸多佐胺; L671152 hydrochloride; MK507 hydrochloride)-陌孚医药/Medlife

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Dorzolamide hydrochloride (Synonyms: 盐酸多佐胺; L671152 hydrochloride; MK507 hydrochloride)

目录号: PL05254 纯度: ≥99%

CAS No. :130693-82-2

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中文名称	Dorzolamide hydrochloride
中文别名	盐酸多佐胺;盐酸杜塞酰胺;(2S,4S)-2-乙基氨基-4-甲基-5,5-二氧-5,7-二硫双环[4.3.0]壬-8,10-二烯-8-磺酰胺盐酸盐;盐酸多佐胺(青光眼治疗药);多佐胺-2-7;盐酸多佐胺(杜塞酰胺);盐酸多佐胺, 盐酸杜塞酰胺;盐酸多佐胺及中间体;Dorzolamide Hydrochloride 盐酸多佐胺;多佐胺;多佐胺系统适用性 EP标准品;多佐胺盐酸盐;抗青光眼药盐酸多佐胺;三唾液酸神经节苷酯;盐酸多佐胺 Dorzolomide hydrochloride;盐酸多佐胺 EP标准品;盐酸多佐胺 USP标准品;盐酸多佐胺标准品;盐酸多佐胺标准品(JP);盐酸杜塞酰胺(标准品)
英文名称	Dorzolamide hydrochloride
英文别名	Dorzolomide hydrochloride;3-b)thiopyran-2-sulfonamide,5,6-dihydro-4-(ethylamino)-6-methyl-4h-thieno(;mk-0507;monohydrochloride,(4s-trans)-7-dioxide;(2s,4s)-2-ethylamino-4-methyl-5,5-dioxo-5,7-dithiabicyclo[4.3.0]nona-8,10-diene-8-sulfonamide hydrochloride;DORZOLAMIDE HCL;DORZOLAMIDE HYDROCHLORIDE;DorzolomideHcl,Usp;4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, hydrochloride (1:1), (4S,6S)-;Dorzolamide;Dorzolamide (hydrochloride);L671152 hydrochloride;MK507 hydrochloride;MK 507;Trusopt;Biosopt;L 671152;Dorzalamide;Dorzolamide HCI;Dorzolamide hydrochloride;(2S,4S)-2-Ethylamino-4-methyl-5,5-dioxo-5,7-dithiabicyclo[4.3.0]nona-8,10-diene-8-sulfonamide hydrochloride
Cas No.	130693-82-2
分子式	C₁₀H₁₆N₂O₄S₃^.HCl
分子量	360.89
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情

Dorzolamide (L671152) hydrochloride 是有效的碳酸酐酶 carbonic anhydrase II 的抑制剂，其对红细胞CA-II 和CA-I 的 IC₅₀ 值分别为 0.18 nM 和 600 nM。

生物活性

Dorzolamide (L671152) hydrochloride is a potent carbonic anhydrase II inhibitor, with IC 50 values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity.

性状

Solid

体外研究(In Vitro)

Component A, caused by an inward flux of CO2 and its subsequent hydration by CA-II, is blocked by Dorzolamide in a dose-dependent manner with an 50% inhibitory concentration IC50 of 2.4 μM (95% confidence interval: 0.5-10.85 μM).
has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Dorzolamide (3, 10, or 30 mg/kg/day, ip) synergized mitomycin C exhibits anti-tumor activity in EAC solid tumor models. Dorzolamide produces a dose-dependent decrease in the calculated ratio (relative value of 57.3±1, 25.5±1.8, and 24.3± 0.7 %, respectively).
has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. J Biollaz, et al. Whole-blood pharmacokinetics and metabolic effects of the topical carbonic anhydrase inhibitor dorzolamide. Eur J Clin Pharmacol. 1995;47(5):455-60.
[2]. Sangly P Srinivas, et al. Inhibition of carbonic anhydrase activity in cultured bovine corneal endothelial cells by dorzolamide. Invest Ophthalmol Vis Sci. 2002 Oct;43(10):3273-8.

溶解度数据	In Vitro: DMSO : 100 mg/mL (277.09 mM; Need ultrasonic)H₂O : 12.5 mg/mL (34.64 mM; Need ultrasonic)配制储备液

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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