Bendamustine hydrochloride|3543-75-7|(盐酸苯达莫司汀; SDX-105)-陌孚医药/Medlife

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Bendamustine hydrochloride (Synonyms: 盐酸苯达莫司汀; SDX-105)

目录号: PL05246 纯度: ≥98%

CAS No. :3543-75-7

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中文名称	Bendamustine hydrochloride
中文别名	盐酸苯达莫司汀;4-[5-[双(2-氯乙基)氨基]-1-甲基苯并咪唑-2-基]丁酸盐酸盐;盐酸苯达莫斯汀;4-[5-[双(2-氯乙基)氨基]-1-甲基苯并咪唑-2-基]丁酸盐酸盐盐酸苯达莫司汀;苯达莫司汀盐酸盐水合物;苯达莫斯汀;盐酸苯达莫司汀(标准品);Bendamustine Hydrochloride Hydrate 苯达莫司汀盐酸盐水合物;苯达莫司汀;盐酸苯达莫司汀BendaMustine hydrochloride;盐酸苯达莫司汀及其杂质;盐酸苯达莫司汀杂质;盐酸苯达莫司汀杂质标准品对照品;盐酸苯达莫司汀杂质对照品;5-[二(2-氯乙基)氨基]-1-甲基苯并咪唑-2-丁酸盐酸盐;研究用抗肿瘤类
英文名称	Bendamustine hydrochloride
英文别名	4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid hydrochloride;BENDAMUSTIN HYDROCHLORIDE;CYTOSTASAN;1-methyl-5-bis(2-chloroethyl)amino-2-benzimidazolinebutryric acid hydrochloride;4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid hydrochloride;1-methyl-5-bis(2-chloroethyl)amino-2-benzimidazolinebutryricacihydrochlor;gamma(1-methyl-5-bis(beta-chloraethyl)aminobenzimidazoyl-2)buttersaeurehydro;BENDAMUSTINE HCL;4-[5-[Bis(2-chloroethyl)amino]-1-methyl-benzimidazol-2-yl]butyric acid hydrochloride;Bendamustine hydrochloride hydrate;4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo-[d]imidazol-2-yl)butanoic acid hydrochloride;Bendamustine hydrochloride;REMODULIN;BendaMustin HCl;Bendamustinhydrochlorid;Bendamustinum;CytostasanHCl;EP3101;EP-3101;Ribomustin;SDX105;SDX-105;Treanda;ZIMET-33;IMET 3393;Treakisym;Bendamustine (hydrochloride);Bendeka;SDX 105;981Y8SX18M;Ribomustine;Levact;Treanda (TN);gamma(1-Methyl-5
Cas No.	3543-75-7
分子式	C₁₆H₂₂Cl₃N₃O₂
分子量	394.72
包装储存	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

产品详情

Bendamustine hydrochloride (SDX-105)，一种嘌呤类似物，是一种 DNA 交联剂。Bendamustine hydrochloride 可激活 DNA 损伤反应和细胞凋亡 (apoptosis)。Bendamustine hydrochloride 具有有效的烷基化，抗癌和抗代谢作用。

生物活性

Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties.

性状

Solid

IC50 & Target[1][2]

DNA Alkylator/Crosslinker

体外研究(In Vitro)

Bendamustine is a DNA cross-linking agent that causes DNA breaks, with alkylating and antimetabolite properties. Bendamustine uniquely regulates apoptosis pathways and DNA repair pathways in non-Hodgkins lymphoma cells. Bendamustine (50 μM) induces p21 (Cip1/Waf1) and NOXA genes, and increases the expression of p53 in SU-DHL-1 cells. Bendamustine (25 μM) blocks mitotic checkpoints and cuases mitotic catastrophe.
Bendamustine reduces the viability of multiple myeloma (MM) cell lines, such as RPMI-8226 and 8226-LR5 cells, with IC25s of 101.8 μM and 585.5 μM after 24 h incubation, and 51.7 and 374.3 μM after 48 h incubation, respectively. Bendamustine induces a specific caspase-dependent MM cell death and inhibits the spindle-assembly checkpoint. has not independently confirmed the accuracy of these methods

体内研究(In Vivo)

Bendamustine (25 mg/kg, i.v.) shows potent inhibition on the growth of tumor cells by 91%, 99% and 95% for DoHH-2, Granta 519 and RAMOS models, respectively. Moreover, the antitumor effect of Bendamustine is enhanced by rituximab in DoHH-2 and RAMOS models, but not in Granta 519 model. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

ClinicalTrial

参考文献

[1]. Leoni LM, et al. Bendamustine (Treanda) displays a distinct pattern of cytotoxicity and unique mechanistic features compared with other alkylating agents. Clin Cancer Res. 2008 Jan 1;14(1):309-17.
[2]. Cives M, et al. Bendamustine overcomes resistance to melphalan in myeloma cell lines by inducing cell death through mitotic catastrophe. Cell Signal. 2013 May;25(5):1108-17.

溶解度数据	In Vitro: DMSO : 100 mg/mL (253.34 mM; Need ultrasonic)H₂O : 12.5 mg/mL (31.67 mM; Need ultrasonic)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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