Pentagastrin (Synonyms: 五肽胃泌素; ICI-50123)
目录号: PL05228 纯度: ≥98%
CAS No. :5534-95-2
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中文名称
Pentagastrin
中文别名
五肽胃泌素;甘氨酰-脯氨酰-对硝基苯胺对甲苯磺酸盐;N-[(1,1-二甲乙氧基)羰基]-Β-丙氨酰-L-色氨酰-L-甲硫氨酰-L-门冬氨酰-L-苯丙酰胺;五肽胃必素
英文名称
Pentagastrin
英文别名
Pentagastrin;Boc-b-Ala-Trp-Met-Asp-Phe-NH2;ICI-50123;ay6608;gastrodiagnost;GRP;lanineamide;pentagastrine;peptavlon;petavlon;petogasrin;N-t-Boc-β-Ala-Trp-Met-Asp-Phe amide;Alaninamide,N-carboxy-b-alanyl-L-tryptophyl-L-methionyl-L-aspartylphenyl-,N-tert-butyl ester, L- (7CI,8CI);L-Phenylalaninamide,N-[(1,1-dimethylethoxy)carbonyl]-b-alanyl-L-tryptophyl-L-methionyl-L-a-aspartyl-;BOC-b-Ala-Try-Met-Asp-Phe(NH2);ICI 50123;N-(a-Carbamoylphenethyl)-3-[2-[2-[3-(carboxyamino)propionamido]-3-indol-3-ylpropionamido]-4-(methylthio)butyramido]succinamicacid N-tert-butyl ester;N-Carboxy-b-alanyl-L-tryptophyl-L-methionyl-L-aspartylphenyl-L-alaninamideN-tert-butyl ester;N-t-Butyloxycarbonyl-b-alanyl-L-tryptophyl-L-methionyl-L-aspartyl-L-phenylalanineamide;NSC 367746;t-Butoxycarbonyl-b-Ala-Trp-Met-Asp-Phe-NH2;AY 6608;Peptavlon
Cas No.
5534-95-2
分子式
C37H49N7O9S
分子量
767.89
包装储存
Sealed storage, away from moisture and lightPowder -80°C 2 years;-20°C 1 year
产品详情
Pentagastrin (ICI-50123) 是一种有效具有选择性的胆囊收缩素 B (CCKB) 受体拮抗剂,对CCKB 和 CCKA 的 IC50 值为 11 nM。Pentagastrin 可增强胃粘膜对酸的防御机制,并保护胃粘膜免受损伤。
生物活性
Pentagastrin (ICI-50123) is a potent, selective Cholecystokinin B (CCK B ) receptor antagonists with IC 50 values of 11 nM and 1100 nM for CCK B and CCK A , respectively. Pentagastrin enhances gastric mucosal defense mechanisms against acid and protects the gastric mucosa from experimental injury..
性状
Solid
IC50 & Target[1][2]
CCKBR
体外研究(In Vitro)
Pentagastrin (ICI-50123) (0.1-100 μM; GH3-cells) increases intracellular Ca in a dose-dependent manner with a maximal increase of 2.77-fold.
Pentagastrin (ICI-50123) (0.1-100 μM; GH3-cells) bounds dose dependently to GH3 cells. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)
Pentagastrin (ICI-50123) (80 μg/kg/h; i.v.; male Sprague-Dawley rats) protects rat gastric mucosa from acidified aspirin injury. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male S
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Sealed storage, away from moisture and lightPowder -80°C 2 years;-20°C 1 year
参考文献
[1]. Smith AJ, et al. Characterisation of CCKB receptors on GH3 pituitary cells: receptor activation is linked to Ca2+ mobilisation. Eur J Pharmacol. 1994 Apr 15;267(2):215-23.
[2]. Tanaka S, et al. Pentagastrin gastroprotection against acid is related to H2 receptor activation but not acid secretion. Gut. 1998 Sep;43(3):334-41.
溶解度数据
In Vitro: DMSO : ≥ 34 mg/mL (44.28 mM)H2O : < 0.1 mg/mL (ultrasonic) (insoluble)
搜索质检报告(COA)

1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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