Grepafloxacin hydrochloride|161967-81-3|-陌孚医药/Medlife

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Grepafloxacin hydrochloride

目录号: PL05217 纯度: ≥99%

CAS No. :161967-81-3

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中文名称	Grepafloxacin hydrochloride
中文别名	盐酸格帕沙星;1-环丙基-6-氟-7-(3-甲基-1-哌嗪基)-5-甲基-1,4-二氢-4-氧代喹啉-3-羧酸盐酸盐;2-氨基-4,4,4-三氟丁酸;格帕沙星
英文名称	Grepafloxacin hydrochloride
英文别名	1-Cyclopropyl-6-fluoro-5-methyl-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride;1-Cyclopropyl-6-fluoro-1,4-dihydro-5-methyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid hydrochloride (1:1);4-Cyclohexene-1,3-dione, 5-hydroxy-2,2,6,6-tetramethyl-4-(1-oxo-3-phenylpropyl)-;5-Hydroxy-2,2,6,6-tetramethyl-4-(1-oxo-3-phenylpropyl)-4-cyclohexene-1,3-dione;AC1MHZY5;grandiflorone;Grepafloxacin hydrochloride;Gpfx;Raxar;D02178;Raxar (tn);GREPAFLOXACIN HCL;Grepafloxacin hydrochloride (jan/usan)
Cas No.	161967-81-3
分子式	C₁₉H₂₂N₃O₃F^.HCl
分子量	395.86
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	Grepafloxacin (OPC-17116) hydrochloride 是一种口服活性氟喹诺酮类抗生素 (antibiotic)，对包括肺炎链球菌在内的社区获得性呼吸道病原体具有有效活性。Grepafloxacin hydrochloride 具有较高的组织渗透性和良好的药效学特性。
生物活性	Grepafloxacin (OPC-17116) hydrochloride is an oral actively fluoroquinolone antibiotic with potent activity against community-acquired respiratory pathogens including Streptococcus pneumonia. Grepafloxacin hydrochloride has high tissue penetration and a promising pharmacodynamic profile.
性状	Solid
IC50 & Target[1][2]	Quinolone
体外研究(In Vitro)	Grepafloxacin (OPC-17116; 0-1 mg/L; 14-21 d) hydrochloride has antibiotic activity with a MIC value of ≤ 0.006 mg/L for E. coli strain. Grepafloxacin (0-1 mg/L; 3 h) hydrochloride has antimicrobial activity against mycobacteria in macrophages with a MIC value of 0.5 mg/L for M. avium . Grepafloxacin hydrochloride exhibits potent in vitro antibacterial activity against Gram-positive bacteria such as Streptococcus pneumoniae and high in vivo efficacy on the experimental systemic infections caused by the Gram-positive and -negative bacteria tested. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Grepafloxacin (OPC-17116; 200 mg/kg; p.o.; Balb/c mice) hydrochloride displays good safety profile in terms of phototoxicity. Grepafloxacin (25-200 mg/kg; p.o.; 5 days/week for 4 weeks; female C57BL6/J-Lyst bg-J/ mice/beige mice) hydrochloride has modest activities in both intranasal (IN) infection and intravenous (IV) Mycobacterium avium infection models. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Vacher S, et, al. Comparative antimycobacterial activities of ofloxacin, ciprofloxacin and grepafloxacin. J Antimicrob Chemother. 1999 Nov;44(5):647-52. [2]. Owen K. Comparative grepafloxacin phototoxicity in mouse skin. J Antimicrob Chemother. 1998 Aug;42(2):261-4. [3]. Cynamon MH, et, al. The activity of grep

溶解度数据	In Vitro: H₂O : ≥ 13.33 mg/mL (33.67 mM)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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