Chenodeoxycholic acid-13C|52918-92-0|(鹅去氧胆酸--陌孚医药/Medlife

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Chenodeoxycholic acid-13C (Synonyms: 鹅去氧胆酸-

目录号: PL05137 纯度: ≥98%

CAS No. :52918-92-0

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中文名称	Chenodeoxycholic acid-13C
中文别名	鹅去氧胆酸-13C同位素;鹅去氧胆酸-13C同位素内标
英文名称	Chenodeoxycholic acid-13C
英文别名	chenodeoxycholic acid-24-13c;CHENODEOXYCHOLIC ACID-13C;(1,2,4,5)-Cyclophan;(2(4))(1,2,4,5)cyclophane;[2.2.2.2](1,2,4,5)Cyclophane;< 2,2,2,2> (1,2,4,5)Cyclophan;< 2.2.2.2> (1,2,4,5)cyclophane;< 2.2.2.2> Cyclophan;< 24> (1,2,4,5)cyclophane;< 24> < 1,2,3,4> cyclophane;< 24-13C> -Chenodeoxycholsaeure;1,2,4,5-(2.2.2.2)-Cyclophane;AC1L3MIF
Cas No.	52918-92-0
分子式	C₂₄H₄₀O₄
分子量	393.56
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	Chenodeoxycholic acid-¹³C 是一种 ¹³C 标记的 Chenodeoxycholic Acid。Chenodeoxycholic Acid 是一种疏水初级胆汁酸，能够活化核受体 FXR，该受体与胆固醇代谢有关。
生物活性	Chenodeoxycholic acid-C is the C-labeled Chenodeoxycholic Acid. Chenodeoxycholic Acid is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism.
性状	Solid
体外研究(In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Stauffer AT, et al. Chenodeoxycholic acid and deoxycholic acid inhibit 11 beta-hydroxysteroid dehydrogenase type 2 and cause cortisol-induced transcriptional activation of the mineralocorticoid receptor. J Biol Chem. 2002 Jul 19;277(29):26286-92

溶解度数据	In Vitro: DMSO : 125 mg/mL (317.61 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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