Acetaminophen-d4|64315-36-2|(Paracetamol-d-陌孚医药/Medlife

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Acetaminophen-d4 (Synonyms: Paracetamol-d

目录号: PL05107 纯度: ≥99%

CAS No. :64315-36-2

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中文名称	Acetaminophen-d4
中文别名	醋氨酚-d4;N-(4-羟苯基-2,3,5,6-d4)乙酰胺;对乙酰氨基酚-D4;对乙酰氨基酚-D4 标准品;对乙酰氨基酚-D4（扑热息痛-D4）;对乙酰氨基酚-D4氘代;对乙酰氨基酚 d4
英文名称	Acetaminophen-d4
英文别名	Acetamide,N-(4-hydroxyphenyl-2,3,5,6-d4)-;Acetaminophen-d4 (major);Acetaminophen-D4;Acetaminophen-(ring-d4);Acetaminophen-D4 solution;ACETAMINOPHEN-D4,WHITE SOLID;Acetaminophene-d4 (Paracetamol-d4);(4- hydroxy-phenyl-2,3,5,6-d4)-acetamide;4-acetylamino-2,3,5,6-tetradeuterio-phenol;4-hydroxy-2,3,5,6-tetradeuterioacetanilide;Acetaminophen-d(4);Paracetamol-d4;Paracetamole-d4;Parageniol-d4;Paralen-d4;Paramol-d4;Paraspen-d4;Valgesic-d4;Vermidon-d4;N-(4-Hydroxyphenyl-2,3,5,6-d4)-acetamide;Paracetamol-(ring-d4);[2H4]-Acetaminophen;[2H4]-Acetoaminophenol;[2H4]-Paracetamol;Acetaminophen-d4
Cas No.	64315-36-2
分子式	C₈H₅D₄NO₂
分子量	155.19
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	Acetaminophen-d₄ 是 Acetaminophen 的氘代物。Acetaminophen (Paracetamol) 是选择性环氧合酶-2 (COX-2) 的抑制剂，IC₅₀ 值为 25.8 μM。Acetaminophen 是一种有效的肝 N-乙酰转移酶 2 (NAT2) 抑制剂。Acetaminophen 是广泛使用的解热和止痛剂。
生物活性	Acetaminophen-d 4 is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent[1][2][3]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[4].
性状	Solid
体外研究(In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Hinz, B, et al. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. FASEB J, 2008. 22(2): p. 383-90. [3]. Miroslav Dini?, et al. Lactobacillus ferm

溶解度数据	In Vitro: DMSO : ≥ 100 mg/mL (644.37 mM)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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