Cycloleucine|52-52-8|(环亮氨酸)-陌孚医药/Medlife

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Cycloleucine (Synonyms: 环亮氨酸)

目录号: PL05015 纯度: ≥98%

CAS No. :52-52-8

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中文名称	Cycloleucine
中文别名	环亮氨酸;1-氨基-1-环戊烷羧酸;环白氨酸;1-氨基环戊烷甲酸;1-氨基-1-环戊羧酸;1-氨基环戊烷羧酸;氨基环戊甲酸;1-Aminocyclopentanecarboxylic Acid 1-氨基环戊烷甲酸;1-氨基-1-环戊基甲酸及合成技术;1-氨基-1-环戊基甲酸;1-氨基环戊烷-1-羧酸
英文名称	Cycloleucine
英文别名	1-Aminocyclopentanecarboxylic acid;1-Amino-1-cyclopentanecarboxylic acid;1-Aminocyclopentanecarboxylate;Cyclopentanecarboxylic acid, 1-amino-;Cycloleucine;1-Aminocyclopentane-1-carboxylic acid;1-amino-1-carboxycyclopentane;1-amino-1-carboxylic cyclopentane;1-Aminocyclopropane-1-carboxylic acid;1-Aminocyclopropane-1-carboxylic acid?;Cyclolencine;Cycloleucine1-Amino-cyclopentanecarboxylic acid;Leucine, Cyclo-;AM20100281;FT-0607341;HY-30008;KBio1_000723;CB 1639;BRN 0636626;DivK1c_000723;BDBM50070638;A829129;CYCLOLEUCINE [HSDB];SY002601;NCGC00163268-01;J-504199;HSDB 5195;Acid, aminocyclopentanecarboxylic;AC5;Cycloleucine1-amino-cyclopentanecarboxylate;1y1m;Spectrum3_001514;CYCLOLEUCIN [WHO-DD];CCG-35835;CB-1639;NCGC00094966-02;NSC 1026;Cyclopentanecarboxylic acid, 1-amino-, L-;4-14-00-00974 (Beilstein Handbook Reference);1-Aminocyclopentanecarboxylicacid;AI3-26442;1-amino cyclopentane carboxylic acid;NINDS_000723;KBioGR_000719;1-amino-1-cyclopentane carboxylic acid;52-52-8;HMS502E05;AS-11677;1-Aminocyclopentane carboxylic acid;Spectrum_001268;CHEBI:40547;Q607775;C03969;3DD7E30B-2149-43D9-A44B-7A59D546A28B;KBioSS_001748;X 201;KBio3_002687;D0P0GT;KBio2_004316;BBL020454;DTXSID5024475;DB04620;1-ammonio-1-cyclopentanecarboxylate;NILQLFBWTXNUOE-UHFFFAOYSA-;Biomol-NT_000201;Spectrum5_001136;NCGC00094966-03;1-amino-cyclopentane carboxylic acid;NCGC00178218-01;NCGC00094966-04;NSC1026;J-802019;SCHEMBL8495;KBio2_006884;STK133034;1 Aminocyclopentanecarboxylic acid;CYCLOPENTANECARBOXYLIC ACID, L-AMINO;1-Amino-1-carboxycyclopentane;A1063;0TQU7668EI;MFCD00001381;AC1OCG3T;CS-B0093;NSC-1026;Z234896477;HMS1921L08;WLN: L5TJ AZ AVQ;Cycloleucine, 97%;LS-173;ZINC00001234;EINECS 200-144-6;Cycloleucin;cycloleucine;1-Amino-cyclopentanecarboxylic acid;CYCLO-LEUCINE;FD1031;UNII-0TQU7668EI;Cyclopentanecarboxylic acid, L-;EN300-39470;InChI=1/C6H11NO2/c7-6(5(8)9)3-1-2-4-6/h1-4,7H2,(H,8,9);SPECTRUM1502128;AC-2700;1-amino-1-Cyclopentanecarboxylate;CHEMBL295830;F8881-4536;BSPBio_003187;Spectrum4_000340;H-NH(1)cPen-OH;NCGC00094966-01;NCIMech_000677;Spectrum2_000931;AKOS000183252;1-amino-Cyclopentanecarboxylate;1-aminocyclopentane-1-carboxylate;(2E)-Decenoyl-ACP;1-aminocyclopentan-1-carboxylsyre;KBio2_001748;aminocyclopentanecarboxylic acid;WR 14997;SPBio_000862;IDI1_000723;NCI60_000070;WR 14,997;BPBio1_001084;Acid, 1-aminocyclopentanecarboxylic;CYCLOLEUCINE [MI]
Cas No.	52-52-8
分子式	C₆H₁₁NO₂
分子量	129.16
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	Cycloleucine 是一种 S-腺苷甲硫氨酸介导的甲基化的特异性抑制剂。Cycloleucine 是 NMDA 受体甘氨酸变构位点的拮抗剂，K_i 值为 600 μM。Cycloleucine 在体外也是 ATP：L-蛋氨酸-S-腺苷基转移酶的竞争性抑制剂。Cycloleucine 具有抗焦虑和抑制细胞作用。
生物活性	Cycloleucine is a specific inhibitor of S-adenosyl-methionine mediated methylation. Cycloleucine is antagonist of NMDA receptor associated glycine receptor, with a K i of 600 μM. Cycloleucine is also a competitive inhibitor of ATP: L-methionine-S-adenosyl transferase in vitro. Cycloleucine has anxiolytic and cytostatic effects.
性状	Solid
IC50 & Target[1][2]	Ki: 600 μM (NMDA)
体外研究(In Vitro)	Cycloleucine (4-40 mM; 3 h) blocks internal methylation of viral RNA in B77 transformed chick embryo fibroblasts. Cycloleucine (40 mM; 24 h) blocks the formation of both mA and the penultimate G in B77 38S RNA subunits by greater than 90%. Cytostatic (10 μg/mL) inhibits the viability human KB and mouse L1210s leukemia cell lines. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Cycloleucine (0.5-4 μg; intracerebroventrical injection) increases time spent in open arms, open arm entries, and extreme arrivals in rats. Cycloleucine reduces thymus and spleen weights in Semliki Forest virus (SFV) strain A7(74) infected and control mice. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Hood WF, et, al. 1-Aminocyclobutane-1-carboxylate (ACBC): a specific antagonist of the N-methyl-D-aspartate receptor coupled glycine receptor. Eur J Pharmacol. 1989 Feb 28;161(2-3):281-2. [2]. Caboche M, et, al. RNA methylation and control of eukaryotic RNA biosynthesis. Effects of cycloleucine, a specific inhibitor of methylation, on ribosomal RNA maturation. Eur J Biochem. 1977 Mar 15;74(1):19-29.

溶解度数据	In Vitro: H₂O : 20 mg/mL (154.85 mM; Need ultrasonic)DMSO : < 1 mg/mL (ultrasonic) (insoluble or slightly soluble)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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