RS-1|312756-74-4|-陌孚医药/Medlife

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RS-1

目录号: PL04950 纯度: ≥98%

CAS No. :312756-74-4

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中文名称	RS-1
中文别名	4-溴-N-(4-溴苯基)-3-[[(苯基甲基)氨基]磺酰基]苯甲酰胺;烯丙基異丙基乙醯脲
英文名称	RS-1
英文别名	4-Bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]benzamide;3-(Benzylsulfamoyl)-4-bromo-N-(4-bromophenyl)benzamide;RS-1;3-[(benzylamino)sulfonyl]-4-bromo-N-(4-bromophenyl)benzamide;AC1LKA12;AG-205;Oprea1_166111;Oprea1_698256;RAD51-stimulatory compound 1;RS1;4-Bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]-benzamide;3-(N-Benzylsulfamoyl)-4-bromo-N-(4-bromophenyl)benzamide;Benzamide, 4-bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]-;4-bromanyl-N-(4-bromophenyl)-3-[(phenylmethyl)sulfamoyl]benzamide;RAD51-Stimulatory Compound-1, RS-1;4-bromo-n-(4-bromophenyl)-3-(((phenylmethyl)amino)sulfonyl)benzamide;3-[(benzylamino)sulfonyl]-4-bromo-N-(4-bromophenyl)benza
Cas No.	312756-74-4
分子式	C₂₀H₁₆Br₂N₂O₃S
分子量	524.23
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	RS-1 是一种 RAD51 的激活剂，同时可增强 CRISPR/Cas9 的活性。
生物活性	RS-1 is a RAD51 activator, and also increases CRISPR/Cas9-mediated knock-in efficiencies.
性状	Solid
IC50 & Target[1][2]	RAD51, CRISPR/Cas9
体外研究(In Vitro)	RS-1 is a RAD51 activator, stimulating binding of hRAD51 to DNA with Kd ranging from 48 nM to 107 nM in the presence of ATP or ADP and in the absence of a nucleotide cofactor, and such an effect is not via inhibiting its ATPase activity. RS-1 (20 μM) affects the length and helical pitch of hRAD51 protein-DNA complexes. RS-1 (0, 1, 5, 10, 15, 20, and 25 μM) stimulates strand assimilation activity of hRAD51. RS-1 (7.5 μM) promotes resistance of human cells to cross-linking chemotherapy. RS-1 (0, 7.5, 15 μM) increases Cas9-mediated knock-in efficiencies in rabbit embryos. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Jayathilaka K, et al. A chemical compound that stimulates the human homologous recombination protein RAD51. Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15848-53. [2]. Song J, et al. RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency. Nat Commun. 2016 Jan 28;7:10548.

溶解度数据	In Vitro: DMSO : ≥ 100 mg/mL (190.76 mM)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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