Caspofungin diacetate (Synonyms: 二醋酸卡泊芬净; MK-0991 diacetate; L-743872 diacetate)
目录号: PL04691 纯度: ≥99%

Caspofungin (MK-0991) diacetate 是一种有效的抗真菌剂。Caspofungin diacetate 抑制 1,3-β-D 葡聚糖合酶的合成。

CAS No. :179463-17-3
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中文名称
Caspofungin diacetate
中文别名
醋酸卡泊芬净;2,2-二甲基丁酰氯;Caspofungin Acetate 抑制剂;醋酸卡泊芬净Casporfungin Acetate;二醋酸卡泊芬净标准品;卡泊芬净醋酸盐;卡泊芬;科赛斯;醋酸考泊芬净;醋酸卡铂芬净;卡泊芬净,醋酸卡泊芬净;CANCIDAS 醋酸卡泊芬净;CASPOFUNGIN ACETATE醋酸卡泊芬净;二醋酸卡泊芬净
英文名称
Caspofungin diacetate
英文别名
Cancidas;Caspofungin acetate;(3S,6S,9S,11R,15S,18S,20R,21S,24S,25S)-21-(2-Aminoethylamino)-3-[3-amino-1(R)-hydroxypropyl]-6-[1(S),2(S)-dihydroxy-2-(4-hydroxyphenyl)ethyl]-18-(10,12-dimethyltetradecanamido)-11,20,25-trihydroxy-15-[1(R)-hydroxyethyl]-1,4,7,13,16,22-hexaazatricyclo[22.3.0.0(9,13)]heptacosane-2,5,8,14,17,23-hexaone diacetate;Caspofungin;Caspofungin (acetate);Gaspofungin;Caspofungin Diacetate;L 743872;L-743,872;L743873;LY231514 disodium;Mk0991;Pemetrexed Disodium;Casp ungin Acetate;Mk 0991;L-743872;L 743873;L 743,872
Cas No.
179463-17-3
分子式
C52H88N10O15.2[C2H4O2]
分子量
1213.42
包装储存
-20°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
产品详情
Caspofungin (MK-0991) diacetate 是一种有效的抗真菌剂。Caspofungin diacetate 抑制 1,3-β-D 葡聚糖合酶的合成。
生物活性
Caspofungin (MK-0991) diacetate is a potent antifungal agent. Caspofungin diacetate inhibits the synthesis of the fungal cell wall component β-(l,3)-D-glucan.
性状
Solid
体内研究(In Vivo)
Caspofungin diacetate (1-8 mg/kg; i.p.; daily, for 7 days) is able to penetrate the CNS in mice and achieve concentrations that result in the reduction of Candida burden in the brain.
Caspofungin diacetate (0.41-41 μM; i.p.; for 5 weeks; male C57BL/6 mice) is a safe antifungal agent at vitreal concentrations of 0.41 to 4.1 μM in mice. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
-20°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
ClinicalTrial
参考文献
[1]. Flattery AM, et, al. Efficacy of caspofungin in a juvenile mouse model of central nervous system candidiasis. Antimicrob Agents Chemother. 2011 Jul;55(7):3491-7.
[2]. Mojumder DK, et, al. Evaluating retinal toxicity of intravitreal caspofungin in the mouse eye. Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5796-803.
溶解度数据
In Vitro: H2O : ≥ 100 mg/mL (82.41 mM)DMSO : 100 mg/mL (82.41 mM; Need ultrasonic)
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1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2